Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | ACR | P10323 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3813706 | 0.82 | MAPT (0.51) | SMN1; SMN2ALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL29185989 | 0.82 | ELANE (0.51) | SMN1; SMN2ALDH1A1MEN1KMT2AELANE | |
| SCHEMBL25688979 | 0.80 | LMNA (0.53) | SMN1; SMN2ALDH1A1RAB9AELANEHPGD | |
| SCHEMBL4736087 | 0.80 | ELANE (0.41) | SMN1; SMN2ALDH1A1RAB9AKMT2AELANE | |
| SCHEMBL11625128 | 0.80 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1KDM4ERAB9AMEN1 | |
| SCHEMBL25407106 | 0.80 | ELANE (0.51) | ALDH1A1KDM4EMEN1KMT2AELANE | |
| SCHEMBL13900227 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1KDM4ERAB9AELANE | |
| SCHEMBL27670799 | 0.79 | ALDH1A1 (0.48) | ALDH1A1KDM4EELANEHPGDMAPT | |
| SCHEMBL27495399 | 0.79 | ELANE (0.40) | SMN1; SMN2ALDH1A1KMT2AELANEMAPT | |
| SCHEMBL25825561 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1KDM4ERAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109748927-A | Heteroaryl amide compound, preparation method, Pharmaceutical composition and its application | 上海交通大学医学院附属瑞金医院 | 2019-05-14 | — | — | CN | disclosed |