Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.44 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamide SCHEMBL5320681 | 0.82 | PARP1 (0.61) | TSHRHSD17B10TDP1CYP2C19POLB | |
| Benzamide SCHEMBL28308326 | 0.81 | PARP1 (0.59) | TSHRHSD17B10TDP1CYP2C19POLB | |
| Benzamide SCHEMBL28875161 | 0.79 | MAPT (0.57) | TSHRHSD17B10TDP1CYP2C19POLB | |
| Benzyl Carbamate SCHEMBL7363448 | 0.78 | ALDH1A1 (0.47) | TSHRTDP1CYP3A4L3MBTL1ALDH1A1 | |
| Propionamide SCHEMBL29663368 | 0.78 | CYP2D6 (0.53) | TSHRHSD17B10TDP1CYP2C19MAPT | |
| Benzamide SCHEMBL8687117 | 0.78 | PARP1 (0.73) | TSHRHSD17B10TDP1CYP2C19POLB | |
| Benzamide SCHEMBL9496452 | 0.78 | PARP1 (0.73) | TSHRHSD17B10TDP1CYP2C19POLB | |
| Benzamide SCHEMBL1637053 | 0.76 | PARP1 (0.76) | TSHRHSD17B10TDP1CYP2C19POLB | |
| Benzamide SCHEMBL2401802 | 0.76 | PARP1 (0.76) | TSHRHSD17B10TDP1CYP2C19POLB | |
| SCHEMBL63935 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110023309-B | Indazole derivatives as glucagon receptor antagonists | 詹森药业有限公司 | 2022-08-09 | — | — | CN | disclosed |
| CN-109923109-B | Indazole derivatives as glucagon receptor antagonists | 詹森药业有限公司 | 2022-06-17 | — | — | CN | disclosed |
| CN-110023309-A | Indazole derivatives as glucagon receptor antagonists | 詹森药业有限公司 | 2019-07-16 | — | — | CN | disclosed |
| CN-109923109-A | Indazole derivatives as glucagon receptor antagonists | 詹森药业有限公司 | 2019-06-21 | — | — | CN | disclosed |