SCHEMBL283066

SCHEMBL283066

COC(=O)Nc1cccc2ccccc12

nearest known ligand 0.71

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.71
HPGD P15428 2/20 0.71
KDM4E B2RXH2 4/20 0.65
GAA P10253 1/20 0.65
CYP1A2 P05177 2/20 0.62
CYP2C19 P33261 2/20 0.62
PLAU P00749 1/20 0.61
KMT2A Q03164 6/20 0.61
MEN1 O00255 5/20 0.61
LMNA P02545 1/20 0.61
HTT P42858 1/20 0.61
RAB9A P51151 4/20 0.60
NPC1 O15118 3/20 0.60
CYP3A4 P08684 1/20 0.59
CYP2D6 P10635 1/20 0.59
CYP2C9 P11712 1/20 0.59
MAPT P10636 2/20 0.57
EPHX1 P07099 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7913708 0.88 ALDH1A1 (0.58) ALDH1A1HPGDKDM4EGAACYP1A2
SCHEMBL2094345 0.84 ALDH1A1 (0.64) ALDH1A1HPGDKDM4EGAACYP1A2
SCHEMBL28294486 0.84 KDM4E (0.68) ALDH1A1HPGDKDM4EGAACYP1A2
SCHEMBL799890 0.83 KDM4E (0.64) ALDH1A1HPGDKDM4EGAACYP1A2
SCHEMBL2396852 0.83 ALDH1A1 (0.63) ALDH1A1HPGDKDM4EGAACYP1A2
SCHEMBL283472 0.83 ALDH1A1 (1.00) ALDH1A1HPGDKDM4EGAACYP1A2
SCHEMBL1600148 0.82 NPC1 (0.61) ALDH1A1HPGDKDM4EGAACYP1A2
SCHEMBL11659356 0.82 HPGD (0.64) ALDH1A1HPGDKDM4EPLAUKMT2A
SCHEMBL30125017 0.82 TRPV1 (0.70) KDM4EPLAUKMT2AMEN1RAB9A
SCHEMBL1413214 0.82 TRPV1 (0.70) KDM4EPLAUKMT2AMEN1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 236 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103562198-A Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity CHIESI FARMA SPA 2014-02-05 CN claimed
CN-100528354-C ZnO/SBA-15 composite nano-catalyst, preparation method and application thereof SHANXI COAL CHEM INST (CN) 2009-08-19 CN claimed
CN-101269342-A ZnO/SBA-15 composite nano-catalyst, preparation method and application thereof SHANXI COAL CHEM INST (CN) 2008-09-24 CN claimed
US-7081481-B2 Excitatory amino acid receptor modulators ELI LILLY AND COMPANY (US) 2006-07-25 US claimed
CN-1709508-A Use of acetylcholinesterase inhibitor for preparing diabetes medicines SHANGHAI SAIDA BIOTECHNOLOGY R (CN) 2005-12-21 CN claimed
CN-1640399-A Use of acetylchloinesterase inhibitor for preparing medicine for treating parkinson's disease SAIDA BIOLOG TECHNOLOGY RES CT (CN) 2005-07-20 CN claimed
US-20040102521-A1 Excitatory amino acid receptor modulators ELI LILLY AND COMPANY 2004-05-27 US claimed
CN-1214612-A Non-aromatic polyorganic acid for enhancing insecticide absorption DONLAR CORP (US) 1999-04-21 CN claimed
WO-1982001301-A1 MECHANISM FOR DE-REPRESSION CONTROL SAMPSON MICHAEL J 1982-04-29 WO claimed
EP-0050504-A1 Mechanism for de-repression control Sampson, Michael James (GB) 1982-04-28 EP claimed
US-4069240-A GROUP 8 METAL CATALYST UNIROYAL, INC. (US) 1978-01-17 US claimed
JP-62106002-A None JP disclosed
CN-111808011-B High penetration composition and its application 泰飞尔生物医药(苏州)有限公司 2024-02-27 CN disclosed
CN-114593974-B Yam powder matrix standard sample containing carbaryl and preparation method thereof 中检科(北京)测试认证有限公司 2022-07-19 CN disclosed
CN-114593974-A Yam powder matrix standard sample containing carbaryl and preparation method thereof 中检科(北京)测试认证有限公司 2022-06-07 CN disclosed
EP-0068297-A1 A new insecticidal composition, processes for its production and its use A. Nattermann & Cie. GmbH (DE) 1983-01-05 EP disclosed
WO-1982001301-A1 MECHANISM FOR DE-REPRESSION CONTROL SAMPSON MICHAEL J 1982-04-29 WO disclosed
EP-0050504-A1 Mechanism for de-repression control Sampson, Michael James (GB) 1982-04-28 EP disclosed
US-4069240-A GROUP 8 METAL CATALYST UNIROYAL, INC. (US) 1978-01-17 US disclosed
US-3954967-A Method of producing microcolloidal aqueous emulsions of unsaturated organic insecticidal compounds VANGUARD CHEMICAL COMPANY, INC. (US) 1976-05-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040102521-A1 Excitatory amino acid receptor modulators GRM1, GRM2, GRIN1 ALDH1A1 1907/4885HPGD 3529/4885KDM4E 1612/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.