SCHEMBL28308385

SCHEMBL28308385

O=C(O)c1nn(-c2cccnc2)cc1O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.51
GAA P10253 4/20 0.51
MAPT P10636 3/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
POLB P06746 1/20 0.51
NPC1 O15118 5/20 0.48
RAB9A P51151 5/20 0.48
KDM4E B2RXH2 4/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
MAPK1 P28482 2/20 0.44
HSD17B10 Q99714 2/20 0.44
TP53 P04637 1/20 0.44
ALOX15 P16050 1/20 0.44
APP P05067 1/20 0.42
HCAR3 P49019 1/20 0.42
HCAR2 Q8TDS4 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2A6 P11509 1/20 0.41
IRAK4 Q9NWZ3 1/20 0.41
HPGD P15428 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21799422 0.87 IRAK4 (0.50) ALDH1A1GAAMAPTL3MBTL1POLB
SCHEMBL14821628 0.84 ALDH1A1 (0.69) ALDH1A1GAAMAPTL3MBTL1POLB
SCHEMBL19019655 0.83 ALDH1A1 (0.53) ALDH1A1GAAMAPTL3MBTL1POLB
SCHEMBL10267021 0.80 NPC1 (0.42) ALDH1A1GAAL3MBTL1NPC1RAB9A
SCHEMBL19019666 0.80 NPC1 (0.74) ALDH1A1MAPTPOLBNPC1RAB9A
SCHEMBL23234411 0.77 CYP17A1 (0.40) ALDH1A1L3MBTL1NPC1RAB9AKDM4E
SCHEMBL30754181 0.77 CYP17A1 (0.40) ALDH1A1L3MBTL1NPC1RAB9AKDM4E
SCHEMBL10290923 0.77 KMT2A (0.48) ALDH1A1MAPTPOLBNPC1RAB9A
Hydrochloric Acid SCHEMBL518722 0.76 KMT2A (0.47) ALDH1A1GAAMAPTPOLBNPC1
SCHEMBL21799396 0.75 SGMS2 (0.49) ALDH1A1HPGDKMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107001383-B Oxygen azatropylidene compound and contain the compound as the insecticide for agricultural or horticultural use of effective component and its application method 日本农药株式会社 2019-07-26 CN disclosed