Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30463490 | 1.00 | MPO (0.41) | MPOHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19262502 | 0.89 | SLC6A2 (0.42) | HTR1ASLC6A2SLC6A4SLC6A3USP7 | |
| SCHEMBL20757966 | 0.87 | CHRNB2 (0.42) | MPOHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18741830 | 0.85 | HTR3A (0.44) | MPOHTR3A | |
| SCHEMBL2636887 | 0.77 | MPO (0.41) | MPOHTR3A | |
| SCHEMBL23439627 | 0.75 | SLC6A2 (0.44) | HTR1ASLC6A2SLC6A4SLC6A3USP7 | |
| SCHEMBL29469994 | 0.74 | MGLL (0.48) | HTR1ASLC6A2SLC6A4SLC6A3USP7 | |
| SCHEMBL19995522 | 0.74 | MPO (0.42) | MPOHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19995524 | 0.74 | MPO (0.42) | MPOHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28239769 | 0.72 | MPO (0.44) | MPOHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110072850-B | 3-sulfonyl-5-aminopyridine-2, 4-diol APJ agonists | 百时美施贵宝公司 | 2023-07-21 | — | — | CN | disclosed |
| CN-110072850-A | 3-sulfonyl-5-aminopyridine-2, 4-diol APJ agonists | 百时美施贵宝公司 | 2019-07-30 | — | — | CN | disclosed |