Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20670426 | 0.85 | GLA (0.42) | GPR119RAB9AKDM4EGLA | |
| SCHEMBL28311838 | 0.74 | GPR119 (0.34) | NR1H2GPR119RORC | |
| SCHEMBL12610885 | 0.72 | ESR2 (0.40) | NR1H2GPR119KDM4EPKM | |
| SCHEMBL19827493 | 0.71 | GPR119 (0.39) | NR1H2GPR119NPC1RAB9AKDM4E | |
| SCHEMBL18651951 | 0.69 | KDM4E (0.38) | NR1H2GPR119KDM4EDDB1CRBN | |
| SCHEMBL7970964 | 0.68 | CHRM2 (0.39) | NR1H2GPR119KDM4EDDB1CRBN | |
| SCHEMBL20220677 | 0.67 | PDE4B (0.38) | NR1H2RORCKDM4EPKMPTPN2 | |
| SCHEMBL28627159 | 0.67 | NR1H2 (0.39) | NR1H2GPR119RORCKDM4E | |
| SCHEMBL2793465 | 0.67 | USP2 (0.37) | NR1H2GPR119RORCKDM4EDDB1 | |
| SCHEMBL656014 | 0.67 | DDB1 (0.44) | NR1H2GPR119KDM4EDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110117245-A | A kind of synthetic method of JAK inhibitor intermediate | 浙江师范大学 | 2019-08-13 | — | — | CN | disclosed |