Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830068 | 0.95 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAMC4RALDH1A1TDP1 | |
| SCHEMBL2826937 | 0.87 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1GAARAB9AKMT2A | |
| SCHEMBL2829765 | 0.86 | KMT2A (0.43) | SMN1; SMN2LMNAALDH1A1TDP1GAA | |
| SCHEMBL2826660 | 0.86 | LMNA (0.46) | SMN1; SMN2LMNAALDH1A1GAAHTT | |
| SCHEMBL2825247 | 0.86 | NPC1 (0.44) | SMN1; SMN2LMNAGAAL3MBTL1RAB9A | |
| SCHEMBL2831135 | 0.83 | NPC1 (0.51) | SMN1; SMN2ALDH1A1RAB9AKMT2ANPC1 | |
| SCHEMBL2829854 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAALDH1A1TDP1HSP90AA1 | |
| SCHEMBL2828482 | 0.82 | NPC1 (0.50) | SMN1; SMN2GAARAB9AKMT2ANPC1 | |
| SCHEMBL2829443 | 0.82 | MEN1 (0.50) | LMNAHTTRAB9AKMT2ANPC1 | |
| SCHEMBL2828420 | 0.82 | GRK2 (0.44) | SMN1; SMN2ALDH1A1TDP1HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |