Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1218083 | 0.83 | CTSK (0.49) | CTSKALDH1A1KMT2A | |
| SCHEMBL13689032 | 0.83 | CTSK (0.49) | CTSKALDH1A1KMT2A | |
| SCHEMBL2780999 | 0.81 | CNR2 (0.34) | CNR2KMT2A | |
| SCHEMBL1218374 | 0.79 | EPHX2 (0.33) | CNR2KDM4E | |
| SCHEMBL12884857 | 0.76 | PKM (0.36) | CTSK | |
| SCHEMBL12898792 | 0.76 | CTSK (0.35) | CTSKKMT2A | |
| Hydrochloric Acid SCHEMBL1218339 | 0.74 | PKM (0.39) | CTSK | |
| SCHEMBL1219536 | 0.71 | KDM4E (0.30) | KDM4EALDH1A1 | |
| SCHEMBL4057500 | 0.70 | — | — | |
| SCHEMBL4057504 | 0.69 | HDAC8 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265335-A1 | INDAZOLE DERIVATIVES | Pfizer Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106982-A1 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |