Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12884853 | 0.84 | KMT2A (0.44) | L3MBTL1 | |
| SCHEMBL13689033 | 0.84 | KMT2A (0.44) | L3MBTL1 | |
| SCHEMBL4049704 | 0.81 | ALDH1A1 (0.40) | EPHX2CNR2KDM4EL3MBTL1 | |
| SCHEMBL2831684 | 0.79 | CTSK (0.34) | CNR2KDM4E | |
| SCHEMBL2780999 | 0.79 | CNR2 (0.34) | CNR2 | |
| SCHEMBL4050841 | 0.79 | EPHX2 (0.38) | EPHX2KDM4EL3MBTL1 | |
| SCHEMBL13689120 | 0.79 | EPHX2 (0.38) | EPHX2KDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL1218441 | 0.78 | EPHX2 (0.37) | EPHX2KDM4EL3MBTL1 | |
| SCHEMBL1218951 | 0.74 | EPHX2 (0.31) | EPHX2 | |
| SCHEMBL12899381 | 0.67 | KMT2A (0.41) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028447-A1 | INDAZOLE DERIVATIVES | PFIZER INC. | 2011-02-03 | — | — | US | disclosed |
| EP-2265335-A1 | INDAZOLE DERIVATIVES | Pfizer Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106982-A1 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028447-A1 | INDAZOLE DERIVATIVES | CNR1, CNR2, GPR119 | EPHX2 1046/4885CNR2 2/4885KDM4E 2463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.