Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Asparagine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 5/20 | 0.54 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.54 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.54 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.54 |
| ▸ | GRM8 | O00222 | 2/20 | 0.54 |
| ▸ | GRM6 | O15303 | 2/20 | 0.54 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.54 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.54 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.54 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.54 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.54 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.54 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.54 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.54 |
| ▸ | GSR | P00390 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.54 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.54 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Asparagine SCHEMBL5639005 | 0.98 | GRIK1 (0.56) | GRIK1GRIK2GRM1GRM2GRM8 | |
| Asparagine SCHEMBL1498267 | 0.91 | ALOX15 (0.54) | GRIK1GRIK2GRM1GRM2GRM8 | |
| Asparagine SCHEMBL1498269 | 0.91 | ALOX15 (0.54) | GRIK1GRIK2GRM1GRM2GRM8 | |
| Asparagine SCHEMBL5327761 | 0.88 | ALOX15 (0.48) | GRIK1GRIK2GRM1GRM2GRM8 | |
| Asparagine SCHEMBL6520765 | 0.88 | ALOX15 (0.48) | GRIK1GRIK2GRM1GRM2GRM8 | |
| Asparagine SCHEMBL8827 | 0.88 | — | — | |
| Asparagine SCHEMBL288093 | 0.88 | ALOX15 (0.56) | GRIK1GRIK2GRM1GRM2GRM8 | |
| Asparagine SCHEMBL20489207 | 0.88 | ALOX15 (0.56) | GRIK1GRIK2GRM1GRM2GRM8 | |
| Asparagine SCHEMBL150535 | 0.88 | ALOX15 (0.56) | GRIK1GRIK2GRM1GRM2GRM8 | |
| Asparagine SCHEMBL4347082 | 0.88 | ALOX15 (0.56) | GRIK1GRIK2GRM1GRM2GRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105886480-B | A kind of whiterot fungi secretion manganese peroxidase culture medium and its application | 安庆师范学院 | 2019-09-10 | — | — | CN | claimed |
| CN-105886480-B | A kind of whiterot fungi secretion manganese peroxidase culture medium and its application | 安庆师范学院 | 2019-09-10 | — | — | CN | disclosed |
| CN-105886480-B | A kind of whiterot fungi secretion manganese peroxidase culture medium and its application | 安庆师范学院 | 2019-09-10 | — | — | CN | disclosed |