Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Asparagine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.46 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.44 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.44 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | GRM8 | O00222 | 1/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Asparagine SCHEMBL5327761 | 1.00 | ALOX15 (0.48) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL366070 | 0.98 | ALOX15 (0.50) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL7998953 | 0.98 | ALOX15 (0.50) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL10011961 | 0.98 | ALOX15 (0.50) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL366069 | 0.98 | ALOX15 (0.50) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL7998952 | 0.98 | ALOX15 (0.50) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL1498267 | 0.93 | ALOX15 (0.54) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL1498269 | 0.93 | ALOX15 (0.54) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL7459478 | 0.91 | ALOX15 (0.45) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL288094 | 0.90 | ALOX15 (0.56) | ALOX15BLMPMP22KMT2AGRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124010-A1 | Whole cell engineering by mutagenizing a substantial portion of a starting genome combining mutations and optionally repeating | DIVERSA CORPORATION | 2005-06-09 | — | — | US | disclosed |