Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | AGER | Q15109 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932828 | 0.89 | KDM4E (0.63) | NAPRTKDM4ETDP1ALDH1A1MAPT | |
| SCHEMBL29442955 | 0.89 | KDM4E (0.63) | NAPRTKDM4ETDP1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL10560254 | 0.87 | KDM4E (0.61) | NAPRTKDM4ETDP1ALDH1A1MAPT | |
| SCHEMBL28317159 | 0.85 | NAPRT (0.45) | NAPRTKDM4ETDP1ALDH1A1MAPT | |
| Glycine SCHEMBL29042666 | 0.79 | NAPRT (0.79) | NAPRTKDM4ETDP1ALDH1A1MAPT | |
| SCHEMBL1379678 | 0.76 | PARP1 (0.56) | NAPRTKDM4ETDP1ALDH1A1MAPT | |
| SCHEMBL30040285 | 0.76 | PARP1 (0.56) | NAPRTKDM4ETDP1ALDH1A1MAPT | |
| SCHEMBL22395413 | 0.75 | P2RX7 (0.64) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| Phthalic Acid SCHEMBL30578745 | 0.75 | ALDH1A1 (0.70) | NAPRTKDM4EALDH1A1MAPTALOX15 | |
| Phthalic Acid SCHEMBL9768559 | 0.75 | ALDH1A1 (0.70) | NAPRTKDM4EALDH1A1MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110204484-A | It is a kind of18The fluorine pyridinecarboxylic glycine and its preparation method and application of F label | 山西医科大学第一医院 | 2019-09-06 | — | — | CN | disclosed |