SCHEMBL932828

SCHEMBL932828

O=C(O)c1cccnc1Br

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.63
TDP1 Q9NUW8 1/20 0.63
ALDH1A1 P00352 6/20 0.61
ALOX15 P16050 2/20 0.61
L3MBTL1 Q9Y468 2/20 0.61
CYP3A4 P08684 1/20 0.61
MAPT P10636 1/20 0.61
TSHR P16473 1/20 0.61
BLM P54132 1/20 0.61
AGER Q15109 1/20 0.61
NPSR1 Q6W5P4 1/20 0.61
NAPRT Q6XQN6 2/20 0.59
LMNA P02545 2/20 0.59
SMN1; SMN2 Q16637 2/20 0.59
DHODH Q02127 2/20 0.50
MYC P01106 1/20 0.49
ALOX12 P18054 1/20 0.46
CYP2C9 P11712 1/20 0.46
KDM6B O15054 1/20 0.46
KDM6A O15550 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29442955 1.00 KDM4E (0.63) KDM4ETDP1ALDH1A1ALOX15L3MBTL1
Hydrochloric Acid SCHEMBL10560254 0.98 KDM4E (0.61) KDM4ETDP1ALDH1A1ALOX15L3MBTL1
Glycine SCHEMBL28318151 0.89 NAPRT (0.53) KDM4ETDP1ALDH1A1ALOX15L3MBTL1
SCHEMBL28317159 0.81 NAPRT (0.45) KDM4ETDP1ALDH1A1ALOX15L3MBTL1
SCHEMBL1972194 0.81 SMN1; SMN2 (0.47) KDM4ETDP1ALDH1A1ALOX15L3MBTL1
SCHEMBL30320721 0.81 KDM4E (0.45) KDM4ETDP1ALDH1A1ALOX15L3MBTL1
SCHEMBL1379678 0.81 PARP1 (0.56) KDM4ETDP1ALDH1A1ALOX15L3MBTL1
SCHEMBL365580 0.81 KDM4E (0.45) KDM4ETDP1ALDH1A1ALOX15L3MBTL1
SCHEMBL30040285 0.81 PARP1 (0.56) KDM4ETDP1ALDH1A1ALOX15L3MBTL1
SCHEMBL4707275 0.80 AKR1C3 (0.52) KDM4ETDP1ALDH1A1ALOX15L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 670 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115521249-B 2- [4- (1-Oxo alkyl) phenoxy ] -3-picolinic acid, preparation method and application thereof 沈阳兴齐眼药股份有限公司 2025-03-11 CN claimed
US-20240343738-A1 Method for preparing pranoprofen and composition comprising pranoprofen and impurity SHENYANG XINGQI PHARMACEUTICAL CO., LTD. (CN) 2024-10-17 US claimed
EP-4361155-A1 METHOD FOR PREPARING PRANOPROFEN AND COMPOSITION CONTAINING PRANOPROFEN AND IMPURITY Shenyang Xingqi Pharmaceutical Co., Ltd. (CN) 2024-05-01 EP claimed
CN-114181179-B Compound containing naphthoquinone oxime structure and medical application of compound as bombesin receptor subtype-3 agonist 上海交通大学 2023-11-24 CN claimed
WO-2022267945-A1 METHOD FOR PREPARING PRANOPROFEN AND COMPOSITION CONTAINING PRANOPROFEN AND IMPURITY 沈阳兴齐眼药股份有限公司 2022-12-29 WO claimed
CN-115521249-A 2- [4- (1-oxoalkyl) phenoxy ] -3-picolinic acid, preparation method and application thereof 沈阳兴齐眼药股份有限公司 2022-12-27 CN claimed
CN-114181179-A Compound containing naphthoquinone oxime structure and medical application of compound as bombesin receptor subtype-3 agonist 上海交通大学 2022-03-15 CN claimed
CN-112375032-A Synthetic method of 3-aminopyridine formaldehyde 苏州康润医药有限公司 2021-02-19 CN claimed
CN-110317204-A Pyrazolopyrimidinonefor derivative and its preparation method and application 安徽农业大学 2019-10-11 CN claimed
CN-104945316-B A kind of method of microwave method synthesis 2- halos nicotinate and its intermediate 山东师范大学 2018-05-04 CN claimed
CN-104945317-B A kind of method of supercritical ultrasonics technology synthesis 2- halos nicotinate and its intermediate 山东师范大学 2018-03-30 CN claimed
CN-107033525-A A kind of anti-fire composite engineering plastics 郑州源冉生物技术有限公司 2017-08-11 CN claimed
CN-106751391-A A kind of anti-fire high-performance composite engineering plastics 郑州源冉生物技术有限公司 2017-05-31 CN claimed
CN-106751852-A A kind of heat-proof combustion-resistant engineering plastics 姚旭 2017-05-31 CN claimed
CN-106633619-A Modified engineering plastic 郑州北斗七星通讯科技有限公司 2017-05-10 CN claimed
US-20260103454-A1 MODULATORS OF HEMOGLOBIN GLOBAL BLOOD THERAPEUTICS INC (US) 2026-04-16 US disclosed
US-12570655-B2 Cysteine covalent modifiers of AKT1 and uses thereof TERREMOTO BIOSCIENCES, INC. (US) 2026-03-10 US disclosed
US-3992536-A SEDATIVES AND MUSCLE RELAXANTS BOEHRINGER INGELHEIM GMBH (DT) 1976-11-16 US disclosed
US-3966736-A 2,9-Dihydro-3H-pyrido[3,2-c]-s-triazolo[4,3-a][1,5]-benzodiazepin-3-ones THE UPJOHN COMPANY (US) 1976-06-29 US disclosed
US-3931185-A SEDATIVES, MUSCLE RELAXANT BOEHRINGER INGELHEIM GMBH (DT) 1976-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12570655-B2 Cysteine covalent modifiers of AKT1 and uses thereof AKT1, AKT2, AKT3 KDM4E 2962/4885TDP1 3565/4885ALDH1A1 3594/4885
US-20240343738-A1 Method for preparing pranoprofen and composition comprising pranoprofen and impurity CYP3A5, CYP3A43, CYP4A11 KDM4E 3123/4885TDP1 991/4885ALDH1A1 205/4885
US-20260103454-A1 MODULATORS OF HEMOGLOBIN HBZ, HBB, HBG2 KDM4E 799/4885TDP1 3514/4885ALDH1A1 1843/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.