Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.53 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.42 |
| ▸ | PPARG | P37231 | 6/20 | 0.42 |
| ▸ | PPARD | Q03181 | 6/20 | 0.42 |
| ▸ | PPARA | Q07869 | 6/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL8843774 | 0.85 | LMNA (0.56) | LMNAALKBH5SUCNR1EGLN1FFAR3 | |
| Succinic Acid SCHEMBL29572406 | 0.85 | FFAR3 (0.48) | LMNAALKBH5SUCNR1EGLN1FFAR3 | |
| Ethanesulfonic Acid Amide SCHEMBL9491342 | 0.84 | FFAR3 (0.41) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL1857902 | 0.84 | LMNA (0.64) | LMNAALKBH5SUCNR1EGLN1FFAR3 | |
| Succinic Acid SCHEMBL11335766 | 0.81 | LMNA (0.60) | LMNAALKBH5SUCNR1EGLN1FFAR3 | |
| Succinic Acid SCHEMBL27383830 | 0.81 | LMNA (0.60) | LMNAALKBH5SUCNR1EGLN1FFAR3 | |
| Succinic Acid SCHEMBL5874907 | 0.78 | LMNA (0.64) | LMNAALKBH5SUCNR1EGLN1FFAR3 | |
| Succinic Acid SCHEMBL5874910 | 0.78 | LMNA (0.64) | LMNAALKBH5SUCNR1EGLN1FFAR3 | |
| Succinic Acid SCHEMBL5874481 | 0.77 | LMNA (0.75) | LMNAALKBH5SUCNR1EGLN1FFAR3 | |
| Succinic Acid SCHEMBL5874486 | 0.77 | LMNA (0.75) | LMNAALKBH5SUCNR1EGLN1FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110382034-A | Method for administering a medicament suitable for treating migraine or cluster headache | 索伦托治疗有限公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-110300612-A | Fluid delivery device with controller assembly and method of use thereof | 索伦托治疗有限公司 | 2019-10-01 | — | — | CN | disclosed |