Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Proflavine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.96 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.75 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.75 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.75 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.75 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.75 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.75 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.75 |
| ▸ | MEN1 | O00255 | 4/20 | 0.75 |
| ▸ | LMNA | P02545 | 3/20 | 0.75 |
| ▸ | HTT | P42858 | 2/20 | 0.75 |
| ▸ | F2 | P00734 | 1/20 | 0.75 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.75 |
| ▸ | MAOA | P21397 | 1/20 | 0.75 |
| ▸ | DRD1 | P21728 | 1/20 | 0.75 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.75 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.75 |
| ▸ | DRD3 | P35462 | 1/20 | 0.75 |
| ▸ | KDR | P35968 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1229699 | 0.98 | HTR3A (1.00) | HTR3AKMT2AMEN1LMNAACHE | |
| Proflavine SCHEMBL3864747 | 0.98 | HTR3A (1.00) | HTR3AKMT2AMEN1LMNAACHE | |
| Hydrochloric Acid SCHEMBL28534457 | 0.94 | HTR3A (0.92) | HTR3AKMT2AMEN1LMNAACHE | |
| Alcohol SCHEMBL29120969 | 0.87 | HTR3A (0.79) | HTR3AKMT2AMEN1LMNAACHE | |
| Proflavine SCHEMBL27386 | 0.87 | KMT2A (1.00) | HTR3AKMT2AMEN1LMNAACHE | |
| Proflavine SCHEMBL29600097 | 0.87 | KMT2A (1.00) | HTR3AKMT2AMEN1LMNAACHE | |
| Sulfuric Acid SCHEMBL28530710 | 0.86 | HTR3A (0.77) | HTR3AKMT2AMEN1LMNAACHE | |
| SCHEMBL30076611 | 0.85 | HTR3A (0.77) | HTR3AKMT2AMEN1LMNAACHE | |
| SCHEMBL1230201 | 0.85 | HTR3A (0.77) | HTR3AKMT2AMEN1LMNAACHE | |
| Proflavine SCHEMBL11072089 | 0.84 | KMT2A (0.77) | HTR3AKMT2AMEN1LMNAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177621-A | METHODS AND SYSTEMS FOR NUCLEIC ACID ANALYSIS AND QUANTIFICATION | 康比纳提公司 | 2019-08-27 | — | — | CN | disclosed |