Proflavine

Proflavine

SCHEMBL11072089

Nc1ccc2cc3ccc(N)cc3nc2c1.Nc1cccc2nc3ccccc3cc12

nearest known ligand 0.77

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 9/20 0.77
ALDH1A1 P00352 9/20 0.77
HPGD P15428 6/20 0.77
KDM4E B2RXH2 5/20 0.77
GLA P06280 3/20 0.77
NPC1 O15118 3/20 0.77
POLB P06746 3/20 0.77
LMNA P02545 2/20 0.77
GAA P10253 2/20 0.77
RAB9A P51151 2/20 0.77
PTBP1 P26599 1/20 0.77
RCE1 Q9Y256 1/20 0.77
HTR3A P46098 1/20 0.74
MEN1 O00255 6/20 0.58
ACHE P22303 3/20 0.58
CHRM2 P08172 2/20 0.58
ADRA2A P08913 2/20 0.58
ADORA3 P0DMS8 2/20 0.58
MAOA P21397 2/20 0.58
DRD1 P21728 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8628036 0.93 KMT2A (0.70) KMT2AALDH1A1HPGDKDM4EGLA
Hydrochloric Acid SCHEMBL28888962 0.92 KMT2A (0.68) KMT2AALDH1A1HPGDKDM4EGLA
SCHEMBL167452 0.88 ALDH1A1 (1.00) KMT2AALDH1A1HPGDKDM4EGLA
SCHEMBL29863459 0.88 ALDH1A1 (1.00) KMT2AALDH1A1HPGDKDM4EGLA
Hydrochloric Acid SCHEMBL590693 0.86 ALDH1A1 (0.96) KMT2AALDH1A1HPGDKDM4EGLA
Proflavine SCHEMBL3864747 0.86 HTR3A (1.00) KMT2AALDH1A1HPGDKDM4EGLA
SCHEMBL1229699 0.86 HTR3A (1.00) KMT2AALDH1A1HPGDKDM4EGLA
Proflavine SCHEMBL28321972 0.84 HTR3A (0.96) KMT2AALDH1A1HPGDKDM4EGLA
SCHEMBL1782937 0.83 KDM4E (0.70) KMT2AALDH1A1HPGDKDM4EGLA
Hydrochloric Acid SCHEMBL28534457 0.83 HTR3A (0.92) KMT2AALDH1A1HPGDKDM4EGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4462993-A REACTION WITH A SUGAR IN PRESENCE OF ACID CATALYST BIOGAL GYOGYSZERGYAR (HU) 1984-07-31 US disclosed