Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 5/20 | 0.38 |
| ▸ | FLT1 | P17948 | 5/20 | 0.38 |
| ▸ | FLT4 | P35916 | 5/20 | 0.38 |
| ▸ | KDR | P35968 | 5/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 3/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | BCR | P11274 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL544201 | 0.84 | RAB9A (0.48) | KITKDRIMPDH2ABL1PDGFRB | |
| SCHEMBL543923 | 0.80 | KIT (0.42) | KITFLT1FLT4KDRALOX5 | |
| SCHEMBL13380736 | 0.78 | KIT (0.43) | KITFLT1FLT4KDRALOX5 | |
| SCHEMBL2831554 | 0.78 | KIT (0.41) | KITIMPDH2ABL1PDGFRBBCR | |
| SCHEMBL5712004 | 0.77 | SMN1; SMN2 (0.51) | KITMEN1LMNAKMT2A | |
| SCHEMBL544093 | 0.76 | MEN1 (0.50) | FLT1FLT4KDRABL1PDGFRB | |
| SCHEMBL544627 | 0.76 | ROCK2 (0.47) | FLT1FLT4KDRMEN1LMNA | |
| SCHEMBL543650 | 0.76 | ALDH1A1 (0.42) | KITFLT1FLT4KDRALOX5 | |
| SCHEMBL543758 | 0.75 | PSEN1 (0.51) | KITFLT1FLT4KDR | |
| SCHEMBL5712010 | 0.75 | MEN1 (0.54) | FLT1FLT4KDRABL1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684750-B1 | 2-AMINOARYLOXAZOLE COMPOUNDS AS TYROSINE KINASE INHIBITORS | AB SCIENCE (FR) | 2010-04-28 | — | — | EP | claimed |