Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4237667 | 0.84 | — | — | |
| Piperazine SCHEMBL28473412 | 0.69 | LMNA (0.40) | — | |
| SCHEMBL15337777 | 0.67 | EPHX1 (0.39) | — | |
| SCHEMBL29926690 | 0.67 | KDM4E (0.33) | — | |
| SCHEMBL10415474 | 0.66 | — | — | |
| Vinylsulfonic Acid SCHEMBL6281464 | 0.64 | MEN1 (0.30) | — | |
| SCHEMBL22042504 | 0.64 | — | — | |
| SCHEMBL3631213 | 0.63 | — | — | |
| SCHEMBL2040906 | 0.60 | TGM2 (0.37) | — | |
| SCHEMBL1291237 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110251680-B | Piperazine divinyl sulfonamide linker and preparation method and application thereof | 上海科技大学 | 2022-10-18 | — | — | CN | claimed |
| CN-110251680-A | A kind of piperazines divinyl sulfonamides link and the preparation method and application thereof | 上海科技大学 | 2019-09-20 | — | — | CN | claimed |
| CN-110251680-B | Piperazine divinyl sulfonamide linker and preparation method and application thereof | 上海科技大学 | 2022-10-18 | — | — | CN | disclosed |
| CN-110251680-B | Piperazine divinyl sulfonamide linker and preparation method and application thereof | 上海科技大学 | 2022-10-18 | — | — | CN | disclosed |
| CN-110251680-B | Piperazine divinyl sulfonamide linker and preparation method and application thereof | 上海科技大学 | 2022-10-18 | — | — | CN | disclosed |
| CN-110251680-A | A kind of piperazines divinyl sulfonamides link and the preparation method and application thereof | 上海科技大学 | 2019-09-20 | — | — | CN | disclosed |
| CN-110251680-A | A kind of piperazines divinyl sulfonamides link and the preparation method and application thereof | 上海科技大学 | 2019-09-20 | — | — | CN | disclosed |
| CN-110251680-A | A kind of piperazines divinyl sulfonamides link and the preparation method and application thereof | 上海科技大学 | 2019-09-20 | — | — | CN | disclosed |