SCHEMBL28328126

SCHEMBL28328126

Cc1ncccc1C(=O)On1ccnc1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.48
TBXAS1 P24557 2/20 0.40
KDM4E B2RXH2 4/20 0.36
AHR P35869 2/20 0.36
NPSR1 Q6W5P4 1/20 0.36
MYC P01106 1/20 0.36
TDP1 Q9NUW8 2/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
HTT P42858 1/20 0.35
BRD4 O60885 1/20 0.34
POLB P06746 1/20 0.34
NPC1 O15118 1/20 0.33
MAPT P10636 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27844090 0.84 KDM4E (0.40) TBXAS1KDM4EAHRNPSR1TDP1
SCHEMBL28223223 0.83 KDM4E (0.42) TBXAS1KDM4EAHRNPSR1TDP1
Isopropylamine SCHEMBL28213782 0.80 KDM4E (0.35) TBXAS1KDM4EAHRNPSR1TDP1
SCHEMBL27598373 0.78 TSHR (0.46) TBXAS1KDM4EAHRNPSR1TDP1
SCHEMBL27323446 0.77 ALDH1A1 (0.42) TBXAS1KDM4EAHRNPSR1TDP1
SCHEMBL27737380 0.77 ALDH1A1 (0.42) TBXAS1KDM4EAHRNPSR1TDP1
SCHEMBL4787316 0.75 P2RX7 (0.47) P2RX7TBXAS1KDM4EAHRMYC
SCHEMBL28957971 0.74 RAB9A (0.40) KDM4ETDP1MEN1KMT2AHTT
SCHEMBL29124585 0.74 P2RX7 (0.48) P2RX7KDM4ENPSR1MYCTDP1
Iodide SCHEMBL19357606 0.73 P2RX7 (0.61) P2RX7KDM4ENPSR1MYCTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116829713-A Hairpin oligonucleotides and uses thereof 芝加哥大学 2023-09-29 CN disclosed
CN-110325540-A Post-transcriptional chemically modified double-stranded RNA 纳诺索尔公司 2019-10-11 CN disclosed