SCHEMBL4787316

SCHEMBL4787316

Cc1ncccc1C(=O)n1ccnc1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.47
TBXAS1 P24557 2/20 0.39
MYC P01106 1/20 0.39
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
POLB P06746 1/20 0.38
NAPRT Q6XQN6 1/20 0.38
KDM4E B2RXH2 2/20 0.36
MAPT P10636 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
CYP24A1 Q07973 1/20 0.36
ELANE P08246 1/20 0.36
NPC1 O15118 1/20 0.35
AHR P35869 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
FAAH O00519 1/20 0.35
MGLL Q99685 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30366356 0.81 FAAH (0.44) TBXAS1ALDH1A1LMNAKDM4EMAPT
SCHEMBL27164904 0.81 NAPRT (0.53) TBXAS1ALDH1A1NAPRTKDM4EMAPT
SCHEMBL15763697 0.81 ELANE (0.55) ALDH1A1LMNAELANE
SCHEMBL2011181 0.78 LMNA (0.53) TBXAS1ALDH1A1LMNAPOLBKDM4E
SCHEMBL7824907 0.76 ALDH1A1 (0.48) TBXAS1ALDH1A1POLBNAPRTKDM4E
SCHEMBL28328126 0.75 P2RX7 (0.48) P2RX7TBXAS1MYCALDH1A1POLB
SCHEMBL10506862 0.74 KMT2A (0.48) ALDH1A1POLBKDM4EMAPTELANE
SCHEMBL395689 0.74 MAPT (0.44) TBXAS1MAPTCYP24A1FAAHMGLL
SCHEMBL16486800 0.74 TBXAS1 (0.42) TBXAS1ALDH1A1KDM4EMAPTCYP24A1
SCHEMBL31664989 0.74 ALDH1A1 (0.50) ALDH1A1POLBKDM4ETDP1ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240052412-A1 METHOD FOR DETECTING RNA STRUCTURE AT WHOLE TRANSCRIPTOME LEVEL AND USE THEREOF TSINGHUA UNIVERSITY (CN) 2024-02-15 US claimed
US-20230374566-A1 METHODS OF IDENTIFYING PROTEIN BINDING SITES ON RNA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-11-23 US claimed
EP-4217364-A1 METHODS OF IDENTIFYING PROTEIN BINDING SITES ON RNA The Regents of the University of California (US) 2023-08-02 EP claimed
US-20230079226-A1 A METHOD OF DETERMINING A STRUCTURE OF RIBONUCLEIC ACID MOLECULES AND RELATED KITS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-03-16 US claimed
US-20220402883-A1 COMPOUNDS AND METHODS FOR MODULATING RNA FUNCTION ARRAKIS THERAPEUTICS, INC. 2022-12-22 US claimed
EP-4103737-A1 A METHOD OF DETERMINING A STRUCTURE OF RIBONUCLEIC ACID MOLECULES AND RELATED KITS Agency for Science, Technology and Research (SG) 2022-12-21 EP claimed
US-20220281860-A1 COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES ARRAKIS THERAPEUTICS, INC. 2022-09-08 US claimed
US-20220267838-A1 Sensitive and Accurate Genome-wide Profiling of RNA Structure In Vivo THE PENN STATE RESEARCH FOUNDATION 2022-08-25 US claimed
WO-2022094863-A1 METHOD FOR DETECTING RNA STRUCTURE AT WHOLE TRANSCRIPTOME LEVEL AND USE THEREOF 清华大学 2022-05-12 WO claimed
WO-2022067036-A1 METHODS OF IDENTIFYING PROTEIN BINDING SITES ON RNA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-03-31 WO claimed
WO-2021162637-A1 A METHOD OF DETERMINING A STRUCTURE OF RIBONUCLEIC ACID MOLECULES AND RELATED KITS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2021-08-19 WO claimed
US-12503455-B2 Nucleic acid-binding photoprobes and uses thereof ARRAKIS THERAPEUTICS, INC. (US) 2025-12-23 US disclosed
US-20250154556-A1 SINGLE-MOLECULE RNA STRUCTURE PROFILING JOHN INNES CENTRE (GB) 2025-05-15 US disclosed
US-20250113829-A1 HIGH MOLECULAR WEIGHT MODIFIED RNA COMPOSITIONS nanoSUR LLC 2025-04-10 US disclosed
EP-4482977-A1 SINGLE-MOLECULE RNA STRUCTURE PROFILING JOHN INNES CENTRE (GB) 2025-01-01 EP disclosed
WO-2015021990-A1 RNA PROBING METHOD AND REAGENTS UNIVERSITY OF COPENHAGEN (DK) 2015-02-19 WO disclosed
WO-2014110272-A1 LOW SEQUENCE BIAS SINGLE-STRANDED DNA LIGATION THE PENN STATE RESEARCH FOUNDATION (US) 2014-07-17 WO disclosed
US-20140193860-A1 Low Sequence Bias Single-Stranded DNA Ligation THE PENN STATE RESEARCH FOUNDATION (US) 2014-07-10 US disclosed
US-20080293712-A1 Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof WYETH (US) 2008-11-27 US disclosed
WO-2008109613-A1 BENZO[C][2,7]NAPHTHYRIDINE DERIVATIVES, AND THEIR USE AS KINASE INHIBITORS WYETH (US) 2008-09-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250113829-A1 HIGH MOLECULAR WEIGHT MODIFIED RNA COMPOSITIONS NSUN2, NSUN3, RNGTT P2RX7 4442/4885TBXAS1 3335/4885MYC 987/4885
US-20220281860-A1 COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES NSUN3, NSUN2, POLRMT P2RX7 3210/4885TBXAS1 1574/4885MYC 547/4885
US-12503455-B2 Nucleic acid-binding photoprobes and uses thereof NSUN3, NSUN2, TARBP1 P2RX7 2442/4885TBXAS1 1011/4885MYC 1033/4885
US-20220402883-A1 COMPOUNDS AND METHODS FOR MODULATING RNA FUNCTION NSUN3, NSUN2, METTL16 P2RX7 2852/4885TBXAS1 2170/4885MYC 553/4885
US-20080293712-A1 Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof PDPK1, PDK2, PDK3 P2RX7 793/4885TBXAS1 826/4885MYC 538/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.