Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28031695 | 0.79 | NPC1 (0.47) | NPC1RAB9ALMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL11416538 | 0.72 | NPSR1 (0.36) | NPC1RAB9ALMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL21061244 | 0.72 | PLA2G7 (0.45) | NPC1RAB9ALMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL6791632 | 0.69 | LMNA (0.41) | NPC1RAB9ALMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL27814455 | 0.69 | ALDH1A1 (0.47) | NPC1RAB9ALMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL9408186 | 0.66 | PLA2G4A (0.38) | NPC1RAB9AHDAC1PLA2G4ACES1 | |
| SCHEMBL27631285 | 0.65 | NPC1 (0.49) | NPC1RAB9ALMNASMN1; SMN2TRPM8 | |
| SCHEMBL160477 | 0.65 | SMN1; SMN2 (0.40) | NPC1RAB9ALMNASMN1; SMN2TSHR | |
| SCHEMBL4267937 | 0.64 | NPC1 (0.47) | NPC1RAB9ALMNASMN1; SMN2TRPM8 | |
| SCHEMBL6798392 | 0.64 | LMNA (0.36) | LMNATRPM8FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110198708-A | Pharmaceutical composition for combination treatment | 基恩菲特公司 | 2019-09-03 | — | — | CN | disclosed |