SCHEMBL28328296

SCHEMBL28328296

O=C(O)c1c(-c2ccccc2)ccc2ccc(O)cc12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.52
CDK4 P11802 3/20 0.48
CCND1 P24385 3/20 0.48
ESR2 Q92731 3/20 0.47
CYP17A1 P05093 3/20 0.47
CYP3A4 P08684 3/20 0.47
CYP11B1 P15538 3/20 0.47
CYP11B2 P19099 3/20 0.47
HSD17B10 Q99714 1/20 0.46
CCNB2 O95067 1/20 0.46
CCNE2 O96020 1/20 0.46
CDK1 P06493 1/20 0.46
CCNB1 P14635 1/20 0.46
CCNE1 P24864 1/20 0.46
CDK2 P24941 1/20 0.46
CCNB3 Q8WWL7 1/20 0.46
NPC1 O15118 1/20 0.45
MIF P14174 1/20 0.45
ESR1 P03372 2/20 0.44
CYP19A1 P11511 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1195261 0.82 MEN1 (0.57) HSD17B10KDM4EMEN1ALDH1A1MAPT
SCHEMBL8418459 0.81 KDM4E (0.56) HSD17B10GAAKDM4EMEN1ALDH1A1
SCHEMBL3388724 0.77 CA12 (0.50) ALOX5ESR2CYP3A4HSD17B10NPC1
SCHEMBL23521242 0.75 FOLH1 (0.53) ALOX5HSD17B10KDM4EMEN1ALDH1A1
SCHEMBL15712652 0.75 CDK4 (0.60) ALOX5CDK4CCND1ESR2CCNB2
SCHEMBL4950823 0.75 KMT2A (0.49) ESR2CYP17A1CYP3A4CYP11B1CYP11B2
SCHEMBL7946060 0.74 MEN1 (0.50) ESR2NPC1ESR1GAARAB9A
SCHEMBL6378389 0.73 MEN1 (0.50) HSD17B10KDM4EMEN1ALDH1A1HPGD
SCHEMBL10783912 0.73 CYP1A2 (0.55) HSD17B10KDM4EMEN1ALDH1A1HPGD
SCHEMBL13966792 0.73 MMP9 (0.55) ALOX5ESR2CYP3A4HSD17B10ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110452211-A The extraction separation method and purposes of 2 noval chemical compounds in root of Japanese banana UNIV GUIZHOU MEDICAL 2019-11-15 CN disclosed