Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | QDPR | P09417 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 9/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.44 |
| ▸ | TLR4 | O00206 | 2/20 | 0.44 |
| ▸ | TLR3 | O15455 | 2/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL310239 | 0.90 | QDPR (0.49) | DRD2KCNH2QDPRTLR9TLR7 | |
| SCHEMBL520088 | 0.83 | QDPR (0.64) | KCNH2QDPRTLR9TLR7CHEK1 | |
| SCHEMBL28137144 | 0.82 | QDPR (0.47) | DRD2KCNH2QDPRTLR9TLR7 | |
| SCHEMBL28136364 | 0.81 | KCNH2 (0.48) | KCNH2QDPRTLR9TLR7TLR4 | |
| SCHEMBL310593 | 0.77 | DRD2 (0.62) | DRD2KCNH2QDPRSLC6A4 | |
| SCHEMBL519694 | 0.76 | QDPR (0.52) | DRD2KCNH2QDPRCHEK1SLC6A4 | |
| SCHEMBL2226718 | 0.76 | CAMK2D (0.49) | DRD2KCNH2QDPRTLR9TLR7 | |
| SCHEMBL18764021 | 0.76 | EGFR (0.49) | QDPRTLR9TLR7TLR4TLR3 | |
| SCHEMBL1285354 | 0.75 | DRD2 (0.50) | DRD2CARM1SLC6A4 | |
| SCHEMBL1264565 | 0.75 | TUBB4A (0.53) | QDPRTUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106536503-B | A kind of tyrosine kinase inhibitor and application thereof | 北京澳合药物研究院有限公司 | 2019-09-06 | — | — | CN | disclosed |
| CN-106536503-A | Tyrosine kinase inhibitor and uses thereof | 山东轩竹医药科技有限公司 | 2017-03-22 | — | — | CN | disclosed |