Toluene

Toluene

SCHEMBL28329972

COc1cc(OC)cc(C(C)Br)c1.Cc1ccccc1

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 3/20 0.42
CA4 P22748 1/20 0.40
ALDH1A1 P00352 2/20 0.39
LMNA P02545 1/20 0.39
TSHR P16473 1/20 0.39
ALOX12 P18054 1/20 0.39
TACR1 P25103 2/20 0.39
CASR P41180 1/20 0.39
BRD4 O60885 1/20 0.38
CREBBP Q92793 1/20 0.38
CYP1A1 P04798 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2E1 P05181 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C8 P10632 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2A6 P11509 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP4B1 P13584 1/20 0.37
CYP2B6 P20813 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27708870 0.84 ALDH1A1 (0.55) ALDH1A1CYP1A1CYP1A2CYP2E1CYP3A4
1,3-Dimethoxybenzene SCHEMBL3728678 0.74 ACHE (0.74) ACHECA4ALDH1A1LMNATSHR
SCHEMBL4428549 0.74 TACR1 (0.48) ACHECA4ALDH1A1TACR1CASR
SCHEMBL4431450 0.73 CASR (0.50) ACHEALDH1A1CASRCYP3A4
Anisole SCHEMBL9794543 0.71 CA4 (0.78) ACHECA4ALDH1A1LMNATSHR
Toluene SCHEMBL28367651 0.71 ACHE (0.69) ACHEALDH1A1LMNATSHRALOX12
SCHEMBL31185919 0.70 RRM1 (0.53) LMNACYP1A2CYP2C19MAOBMEN1
Toluene SCHEMBL5205324 0.69 ACHE (0.79) ACHECA4LMNATSHRALOX12
SCHEMBL903695 0.69 ALDH1A1 (0.58) ALDH1A1CYP1A1CYP1A2CYP2E1CYP3A4
SCHEMBL4819668 0.68 BRD4 (0.57) CA4ALDH1A1LMNAALOX12TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106456573-B Functionalized 1, 3-benzenediols for treating hepatic encephalopathy and methods of use thereof 康纳生物技术有限公司 2019-12-03 CN disclosed