Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.62 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9893477 | 0.87 | SIRT2 (0.63) | MAPTSIRT2SIRT1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9893475 | 0.86 | SIRT2 (0.61) | MAPTSIRT2SIRT1KDM4EALDH1A1 | |
| SCHEMBL14096532 | 0.84 | KMT2A (0.72) | MAPTKDM4EALDH1A1RAB9ANPSR1 | |
| SCHEMBL14096440 | 0.82 | EPHX1 (0.78) | MAPTALDH1A1RAB9AEPHX1NPSR1 | |
| SCHEMBL907582 | 0.81 | SIRT1 (0.65) | MAPTSIRT2SIRT1KDM4EALDH1A1 | |
| SCHEMBL104524 | 0.81 | SMN1; SMN2 (0.61) | MAPTKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL16229385 | 0.80 | SIRT2 (0.78) | SIRT2SIRT1 | |
| SCHEMBL17826598 | 0.79 | SIRT2 (0.77) | MAPTSIRT2SIRT1 | |
| SCHEMBL4178607 | 0.79 | ALDH1A1 (0.56) | MAPTSIRT2SIRT1KDM4EALDH1A1 | |
| SCHEMBL23844169 | 0.78 | LMNA (0.76) | MAPTKDM4EALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110478344-B | Application of acylthiourea compound in preparation of anti-influenza B virus medicine | 武汉大学 | 2022-07-19 | — | — | CN | disclosed |
| CN-110483425-B | Acyl thiourea compound, preparation method thereof and application of acyl thiourea compound in resisting influenza A virus | 武汉大学 | 2021-07-20 | — | — | CN | disclosed |
| CN-110478344-A | A kind of acyl thiourea compound is preparing the application in anti-influenza B virus drug | UNIV WUHAN | 2019-11-22 | — | — | CN | disclosed |
| CN-110483425-A | A kind of application of the acyl thiourea compound and preparation method thereof with anti-influenza A virus | UNIV WUHAN | 2019-11-22 | — | — | CN | disclosed |