Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | GAA | P10253 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.55 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.51 |
| ▸ | KIF11 | P52732 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9453890 | 0.83 | ALDH1A1 (0.65) | ALDH1A1GAASMN1; SMN2KMT2ALMNA | |
| SCHEMBL1027400 | 0.81 | KIF11 (0.61) | SMN1; SMN2KMT2ALMNAMAPTHPGD | |
| SCHEMBL4167105 | 0.81 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KMT2ALMNAMAPT | |
| SCHEMBL28330755 | 0.79 | MAPT (0.64) | ALDH1A1SMN1; SMN2KMT2ALMNAMAPT | |
| SCHEMBL14129389 | 0.78 | ALDH1A1 (0.57) | ALDH1A1GAASMN1; SMN2KMT2ALMNA | |
| SCHEMBL23728134 | 0.77 | EPHX1 (0.71) | ALDH1A1GAASMN1; SMN2KMT2ALMNA | |
| SCHEMBL18401220 | 0.77 | RAB9A (0.56) | ALDH1A1GAASMN1; SMN2KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL9893477 | 0.77 | SIRT2 (0.63) | ALDH1A1SMN1; SMN2KMT2ALMNAMAPT | |
| SCHEMBL457452 | 0.77 | MAPT (0.63) | ALDH1A1GAASMN1; SMN2KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL9893475 | 0.76 | SIRT2 (0.61) | ALDH1A1SMN1; SMN2KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090004185-A1 | AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF BETA-CATENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS | WYETH (US) | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090004185-A1 | AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF BETA-CATENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS | TCF4, CTNNB1, TCF7 | ALDH1A1 2808/4885GAA 3406/4885SMN1; SMN2 4786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.