Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4391684 | 0.91 | ALDH1A1 (0.72) | L3MBTL3KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL4380538 | 0.90 | ALDH1A1 (0.74) | L3MBTL3KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL2833225 | 0.85 | KMT2A (0.80) | L3MBTL3KMT2AALDH1A1TSHRTDP1 | |
| SCHEMBL13636494 | 0.81 | ALDH1A1 (0.69) | L3MBTL3KMT2AALDH1A1TSHRFKBP1A | |
| SCHEMBL14218117 | 0.79 | GAA (0.53) | KMT2AALDH1A1TSHRMEN1FKBP1A | |
| SCHEMBL2833214 | 0.78 | KMT2A (0.69) | L3MBTL3KMT2AALDH1A1TSHRTDP1 | |
| SCHEMBL4381831 | 0.76 | RAB9A (0.55) | KMT2AALDH1A1TSHRMEN1FKBP1A | |
| SCHEMBL4383272 | 0.75 | ALDH1A1 (0.98) | L3MBTL3KMT2AALDH1A1TSHRMEN1 | |
| SCHEMBL2833221 | 0.75 | L3MBTL3 (0.59) | L3MBTL3KMT2AALDH1A1TSHRTDP1 | |
| SCHEMBL23682658 | 0.75 | L3MBTL3 (1.00) | L3MBTL3KMT2AALDH1A1TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |