Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 4/20 | 0.42 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.42 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HCN1 | O60741 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829282 | 0.99 | AR (0.44) | ARL3MBTL1L3MBTL3L3MBTL4MBTD1 | |
| SCHEMBL4380837 | 0.92 | AR (0.44) | ARL3MBTL1LMNANPC1USP2 | |
| SCHEMBL4381900 | 0.91 | HCN1 (0.46) | ARLMNANPC1USP2ALDH1A1 | |
| SCHEMBL4378980 | 0.80 | AR (0.47) | ARL3MBTL1ALDH1A1MAPTHPGD | |
| SCHEMBL4383151 | 0.78 | AR (0.45) | ARL3MBTL1LMNAALDH1A1MAPT | |
| SCHEMBL5216873 | 0.77 | DRD2 (0.44) | ARLMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4378240 | 0.77 | AR (0.44) | ARLMNAALDH1A1MAPTMAPK1 | |
| SCHEMBL2833291 | 0.76 | SMN1; SMN2 (0.49) | ARL3MBTL1L3MBTL3L3MBTL4MBTD1 | |
| SCHEMBL13090286 | 0.76 | SMN1; SMN2 (0.49) | ARL3MBTL1L3MBTL3L3MBTL4MBTD1 | |
| SCHEMBL2829096 | 0.73 | ALDH1A1 (0.51) | L3MBTL1L3MBTL3LMNANPC1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |