Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.69 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.69 |
| ▸ | NAMPT | P43490 | 4/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | GFER | P55789 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nicotinic Acid Hydrazide SCHEMBL29648965 | 0.87 | HDAC1 (0.69) | ROCK2ROCK1RAB9ASMN1; SMN2NPC1 | |
| Nicotinic Acid Hydrazide SCHEMBL258390 | 0.87 | HDAC1 (0.69) | ROCK2ROCK1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3093627 | 0.86 | ROCK2 (0.71) | ROCK2ROCK1NAMPTRAB9ASMN1; SMN2 | |
| SCHEMBL29596226 | 0.86 | ROCK2 (0.71) | ROCK2ROCK1NAMPTRAB9ASMN1; SMN2 | |
| Nicotinic Acid Hydrazide SCHEMBL28747918 | 0.85 | HDAC1 (0.67) | ROCK2ROCK1RAB9ASMN1; SMN2NPC1 | |
| Nicotinic Acid Hydrazide SCHEMBL31491467 | 0.85 | HDAC1 (0.67) | ROCK2ROCK1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL22983024 | 0.85 | ROCK2 (0.69) | ROCK2ROCK1NAMPTRAB9ASMN1; SMN2 | |
| SCHEMBL7329481 | 0.84 | ROCK2 (0.73) | ROCK2ROCK1NAMPTRAB9ASMN1; SMN2 | |
| SCHEMBL3093633 | 0.84 | CYP3A4 (0.82) | ROCK2ROCK1NAMPTRAB9ASMN1; SMN2 | |
| SCHEMBL21391312 | 0.83 | ROCK2 (0.71) | ROCK2ROCK1NAMPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168101-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2010-07-01 | — | — | US | disclosed |
| EP-1439834-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-07-28 | — | — | EP | disclosed |
| WO-2003037328-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168101-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | PTPRO, PTPRE, PTPRZ1 | ROCK2 2548/4885ROCK1 1317/4885NAMPT 1926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.