Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.71 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 8/20 | 0.69 |
| ▸ | NPC1 | O15118 | 6/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | GFER | P55789 | 1/20 | 0.66 |
| ▸ | NAMPT | P43490 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22983024 | 0.86 | ROCK2 (0.69) | ROCK2ROCK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7329481 | 0.86 | ROCK2 (0.73) | ROCK2ROCK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1971026 | 0.86 | NAMPT (0.78) | ROCK2ROCK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL12078341 | 0.86 | NAMPT (0.77) | RAB9ANPC1SMN1; SMN2LMNAHIF1A | |
| SCHEMBL14880158 | 0.85 | RAB9A (0.70) | ROCK2ROCK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL29596226 | 0.84 | ROCK2 (0.71) | ROCK2ROCK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6602214 | 0.84 | ROCK2 (0.71) | ROCK2ROCK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3093627 | 0.84 | ROCK2 (0.71) | ROCK2ROCK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5384036 | 0.84 | ROCK2 (0.76) | ROCK2ROCK1RAB9ANPC1SMN1; SMN2 | |
| Nicotinanilide SCHEMBL352439 | 0.83 | LMNA (0.83) | ROCK2ROCK1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647673-B2 | Acetophenone compound, preparation method thereof, and application thereof in fatty liver prevention and treatment | Nanjing Bioenergy Medicine Science & Technology Co., Ltd. (CN) | 2020-05-12 | — | — | US | disclosed |
| US-20190292153-A1 | Acetophenone Compound, Preparation Method Thereof, And Application Thereof In Fatty Liver Prevention And Treatment | Nanjing Bioenergy Medicine Science & Technology Co., Ltd. (CN) | 2019-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647673-B2 | Acetophenone compound, preparation method thereof, and application thereof in fatty liver prevention and treatment | LIPC, CYP27A1, HSD17B10 | ROCK2 3391/4885ROCK1 3055/4885RAB9A 4025/4885 |
| US-20190292153-A1 | Acetophenone Compound, Preparation Method Thereof, And Application Thereof In Fatty Liver Prevention And Treatment | LIPC, CYP27A1, HSD17B10 | ROCK2 3391/4885ROCK1 3055/4885RAB9A 4025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.