Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.51 |
| ▸ | FLT4 | P35916 | 9/20 | 0.48 |
| ▸ | KDR | P35968 | 9/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.48 |
| ▸ | TEK | Q02763 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 5/20 | 0.46 |
| ▸ | BRAF | P15056 | 5/20 | 0.46 |
| ▸ | FLT1 | P17948 | 8/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28343529 | 0.90 | FLT4 (0.53) | FLT4KDRPDGFRBRAF1BRAF | |
| SCHEMBL168388 | 0.85 | AXL (0.71) | AXLKDRPDGFRBAURKBAURKA | |
| SCHEMBL664744 | 0.83 | KDR (0.70) | AXLFLT4KDRPDGFRBTEK | |
| SCHEMBL29631712 | 0.83 | AXL (0.71) | AXLFLT4KDRPDGFRBTEK | |
| SCHEMBL15084626 | 0.83 | AXL (0.71) | AXLFLT4KDRPDGFRBTEK | |
| SCHEMBL15084518 | 0.82 | KDR (0.67) | AXLFLT4KDRPDGFRBTEK | |
| SCHEMBL15084560 | 0.81 | KDR (0.66) | AXLFLT4KDRPDGFRBTEK | |
| SCHEMBL15084515 | 0.81 | KDR (0.66) | AXLFLT4KDRPDGFRBTEK | |
| SCHEMBL7005111 | 0.81 | DRD3 (0.48) | — | |
| SCHEMBL15084599 | 0.80 | ABCB11 (0.67) | AXLFLT4KDRPDGFRBTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110520416-B | Polysubstituted pyridone derivative, preparation method and medical application thereof | 北京越之康泰生物医药科技有限公司 | 2022-06-03 | — | — | CN | disclosed |
| CN-110520416-A | Polysubstituted pyridine ketones derivant, preparation method and its medical usage | BEIJING YUEZHIKANGTAI BIOMEDICINES CO LTD | 2019-11-29 | — | — | CN | disclosed |