Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 10/20 | 0.61 |
| ▸ | TYMS | P04818 | 4/20 | 0.55 |
| ▸ | GART | P22102 | 3/20 | 0.55 |
| ▸ | ATIC | P31939 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | TLR4 | O00206 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29003723 | 0.99 | DHFR (0.60) | DHFRTYMSGARTATICKDM4E | |
| SCHEMBL8768814 | 0.93 | DHFR (0.61) | DHFRTYMSGARTATICKDM4E | |
| SCHEMBL5427457 | 0.91 | DHFR (0.59) | DHFRTYMSGARTATICKDM4E | |
| SCHEMBL28273767 | 0.91 | DHFR (0.59) | DHFRTYMSGARTATICKDM4E | |
| SCHEMBL3846647 | 0.91 | DHFR (0.61) | DHFRTYMSGARTATICKDM4E | |
| SCHEMBL338037 | 0.91 | DHFR (0.57) | DHFRTYMSGARTATICKDM4E | |
| SCHEMBL1250396 | 0.90 | DHFR (0.62) | DHFRTYMSGARTATICKDM4E | |
| SCHEMBL25167471 | 0.90 | DHFR (0.57) | DHFRTYMSGARTATICKDM4E | |
| SCHEMBL20486467 | 0.90 | DHFR (0.57) | DHFRTYMSGARTATICKDM4E | |
| SCHEMBL869876 | 0.90 | DHFR (0.57) | DHFRTYMSGARTATICKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116162704-A | System for leukemia diagnosis and treatment | 杭州赫玛生物科技有限公司 | 2023-05-26 | — | — | CN | claimed |
| CN-108883069-B | Esterification/saponification based process for micro-lipid loading | 中央研究院 | 2021-07-20 | — | — | CN | claimed |
| CN-116754756-A | Methotrexate detection kit | 北京九强生物技术股份有限公司 | 2023-09-15 | — | — | CN | disclosed |
| CN-111487208-B | Glucose 6-phosphate dehydrogenase mutant and application thereof in preparation of methotrexate detection reagent | 北京九强生物技术股份有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-116381253-A | Method for preparing conjugate | 北京九强生物技术股份有限公司 | 2023-07-04 | — | — | CN | disclosed |
| CN-116298330-A | Use of conjugates in the preparation of detection reagents | 北京九强生物技术股份有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-115698321-A | Methods for plasma free RNA analysis | 格里尔公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-115003317-A | Method of treating atopic dermatitis | 伊奇罗夫科技有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-106573074-B | Bioactive molecule conjugates, reagents and methods of preparation and therapeutic uses thereof | 里珍纳龙药品有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-109419814-B | Application of paradisella gordonii to inhibition of fatty liver disease | 长庚生物科技股份有限公司 | 2021-09-28 | — | — | CN | disclosed |
| CN-107921047-B | Novel use of arylquinoline derivatives as angiogenesis mimicry inhibitors | 台睿生物科技股份有限公司 | 2021-06-01 | — | — | CN | disclosed |
| CN-112755193-A | Method of treating malignancies with anti-tyrosine kinase inhibitors using dianhydrogalactitol or a derivative thereof | 德玛医药 | 2021-05-07 | — | — | CN | disclosed |
| CN-106164293-B | Aptamer constructs | 迪肯大学 | 2020-03-27 | — | — | CN | disclosed |
| CN-110711188-A | Use of substituted hexitols for the treatment of malignant tumors | 德玛公司 | 2020-01-21 | — | — | CN | disclosed |