Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30685514 | 0.86 | OPRL1 (0.35) | OPRL1ALDH1A1TSHRDPP4DPP8 | |
| SCHEMBL2835752 | 0.80 | OPRL1 (0.33) | OPRL1ALDH1A1CYP2D6 | |
| SCHEMBL2053963 | 0.72 | LMNA (0.36) | OPRL1ALDH1A1TSHRDPP4DPP8 | |
| SCHEMBL2837448 | 0.71 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL2832282 | 0.71 | EPHX1 (0.41) | ALDH1A1CYP3A4 | |
| SCHEMBL2832274 | 0.71 | TRPV1 (0.33) | SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL2833004 | 0.71 | FAAH (0.31) | SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL2016931 | 0.71 | LMNA (0.38) | OPRL1SMN1; SMN2ALDH1A1TSHRDPP4 | |
| SCHEMBL3797646 | 0.69 | ALDH1A1 (0.35) | OPRL1ALDH1A1TSHRDPP4DPP8 | |
| SCHEMBL2040851 | 0.69 | LMNA (0.39) | OPRL1SMN1; SMN2ALDH1A1TSHRDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557824-B2 | Thiazole derivatives | MERCK PATENT GMBH (DE) | 2013-10-15 | — | — | US | disclosed |
| US-20100240676-A1 | THIAZOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240676-A1 | THIAZOLE DERIVATIVES | CCNE2, PKD1, PKD2 | OPRL1 1746/4885SMN1; SMN2 3257/4885ALDH1A1 1055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.