Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPI | P34949 | 2/20 | 0.64 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PMM2 | O15305 | 1/20 | 0.49 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11410044 | 0.83 | TSHR (0.64) | MPIALDH1A1RAB9APMM2PHOSPHO1 | |
| SCHEMBL30423702 | 0.79 | TP53 (0.62) | MPITRPV1ALDH1A1SMN1; SMN2ALOX5 | |
| SCHEMBL2438599 | 0.78 | MPI (1.00) | MPITRPV1ALOX5GAATSHR | |
| SCHEMBL30423726 | 0.78 | MPI (1.00) | MPITRPV1ALOX5GAATSHR | |
| SCHEMBL24445253 | 0.77 | HTR3A (0.43) | MPIALDH1A1RAB9APMM2PHOSPHO1 | |
| SCHEMBL4142034 | 0.77 | MPI (0.76) | MPITRPV1ALDH1A1RAB9ANPC1 | |
| SCHEMBL28345371 | 0.76 | MPI (0.73) | MPITRPV1ALDH1A1POLBALOX5 | |
| SCHEMBL28345280 | 0.76 | MPI (0.73) | MPITRPV1RAB9APMM2PHOSPHO1 | |
| SCHEMBL29552755 | 0.76 | MPI (0.73) | MPITRPV1ALDH1A1PMM2ALOX5 | |
| SCHEMBL28396372 | 0.76 | MPI (0.73) | MPITRPV1ALDH1A1RAB9APMM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110655521-B | 12H-indazole [2,1-a ] cinnoline-12-ketone compound and application thereof | 浙江工业大学 | 2020-10-27 | — | — | CN | disclosed |
| CN-110655521-A | 12H-indazole [2,1-a ] cinnoline-12-ketone compound and application thereof | 浙江工业大学 | 2020-01-07 | — | — | CN | disclosed |