SCHEMBL28347446

SCHEMBL28347446

CCCc1nc(C(N)=O)cnc1C(N)=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.40
SIRT6 Q8N6T7 2/20 0.39
TSHR P16473 3/20 0.35
ADORA3 P0DMS8 1/20 0.35
MC4R P32245 1/20 0.35
ADRA1A P35348 1/20 0.35
MC3R P41968 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.34
SYK P43405 2/20 0.33
KCNH2 Q12809 1/20 0.33
LMNA P02545 2/20 0.32
USP2 O75604 1/20 0.32
POLB P06746 1/20 0.32
KMT2A Q03164 2/20 0.32
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31156798 0.85 HSP90AA1 (0.39) HSP90AA1SIRT6TSHRADORA3MC4R
SCHEMBL28344658 0.84 SIRT6 (0.39) SIRT6TSHRADORA3MC4RADRA1A
SCHEMBL28344636 0.83 SIRT6 (0.44) SIRT6TSHRADORA3MC4RADRA1A
SCHEMBL30145632 0.83 SIRT6 (0.44) SIRT6TSHRADORA3MC4RADRA1A
SCHEMBL4864337 0.77 GABRP (0.38) SIRT6TSHRADORA3MC4RADRA1A
SCHEMBL30482995 0.77 SIRT6 (0.42) SIRT6TSHRADORA3MC4RADRA1A
SCHEMBL3286589 0.75 SIRT6 (0.47) SIRT6TSHRADORA3MC4RADRA1A
SCHEMBL21439468 0.74 SMN1; SMN2 (0.37) HSP90AA1TSHRADORA3MC4RADRA1A
SCHEMBL31046847 0.74 SMN1; SMN2 (0.37) HSP90AA1TSHRADORA3MC4RADRA1A
SCHEMBL30301164 0.74 DGAT1 (0.40) HSP90AA1SIRT6TSHRADORA3MC4R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110545854-A method for renal function determination MEDIBEACON INC 2019-12-06 CN disclosed