Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20427511 | 0.79 | LMNA (0.41) | LMNATSHRCHRM2CHRM4CHRM5 | |
| SCHEMBL5665771 | 0.73 | LMNA (0.41) | LMNATSHRCHRM2CHRM4CHRM5 | |
| SCHEMBL16987582 | 0.73 | LMNA (0.41) | LMNATSHRCHRM2CHRM4CHRM5 | |
| SCHEMBL19500214 | 0.73 | LMNA (0.41) | LMNATSHRCHRM2CHRM4CHRM5 | |
| SCHEMBL5107291 | 0.72 | LMNA (0.40) | LMNATSHRCHRM2CHRM4CHRM5 | |
| SCHEMBL5107294 | 0.72 | LMNA (0.40) | LMNATSHRCHRM2CHRM4CHRM5 | |
| SCHEMBL528013 | 0.70 | LMNA (0.39) | LMNATSHRCHRM2CHRM4CHRM5 | |
| SCHEMBL12493193 | 0.70 | LMNA (0.39) | LMNATSHRCHRM2CHRM4CHRM5 | |
| SCHEMBL27832426 | 0.69 | CAD (0.33) | LMNATSHRCYP2C9CYP3A4NFKB1 | |
| SCHEMBL20747653 | 0.69 | LMNA (0.39) | LMNATSHRCYP2C9CYP3A4NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104603113-B | Novel 2, 3-dihydro-1H-imidazo {1,2-a } pyrimidin-5-one and 1,2,3, 4-tetrahydropyrimidino {1,2-a } pyrimidin-6-one derivatives comprising substituted morpholines, preparation thereof and pharmaceutical use thereof | 赛诺菲 | 2020-01-21 | — | — | CN | disclosed |