SCHEMBL28354065

SCHEMBL28354065

COc1ccc(C(=O)NC(C)c2ccc(OC)cc2)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 2/20 0.70
TAS1R1 Q7RTX1 2/20 0.70
CNR1 P21554 2/20 0.67
NPC1 O15118 3/20 0.60
RAB9A P51151 2/20 0.60
MEN1 O00255 1/20 0.60
KMT2A Q03164 1/20 0.60
CYP3A4 P08684 2/20 0.59
CYP1A2 P05177 1/20 0.59
CYP2C9 P11712 1/20 0.59
CYP2C19 P33261 1/20 0.59
ACACB O00763 1/20 0.59
ALDH1A1 P00352 4/20 0.58
CA1 P00915 2/20 0.58
CA2 P00918 2/20 0.58
PLK1 P53350 1/20 0.58
HPGD P15428 1/20 0.57
GAA P10253 1/20 0.57
NR1H4 Q96RI1 1/20 0.56
SMN1; SMN2 Q16637 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12279565 0.94 CA1 (0.70) TAS1R3TAS1R1CNR1NPC1RAB9A
SCHEMBL3241450 0.92 ALDH1A1 (0.69) TAS1R3TAS1R1CNR1NPC1RAB9A
SCHEMBL2641131 0.92 SMN1; SMN2 (0.68) TAS1R3TAS1R1CNR1NPC1RAB9A
SCHEMBL5683032 0.92 SMN1; SMN2 (0.68) TAS1R3TAS1R1CNR1NPC1RAB9A
SCHEMBL3109362 0.87 ROCK1 (0.74) TAS1R3TAS1R1CYP3A4CYP2C9ALDH1A1
SCHEMBL1320543 0.85 MEN1 (0.64) TAS1R3TAS1R1CNR1NPC1RAB9A
SCHEMBL8330051 0.85 CA1 (0.66) TAS1R3TAS1R1NPC1RAB9AMEN1
SCHEMBL700732 0.84 TAS1R3 (0.75) TAS1R3TAS1R1CNR1NPC1RAB9A
SCHEMBL700731 0.84 TAS1R3 (0.75) TAS1R3TAS1R1CNR1NPC1RAB9A
SCHEMBL28615353 0.84 TGM2 (0.66) TAS1R3TAS1R1CNR1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110776447-A Substituted alkyl diaryl derivatives, preparation method and use 坦普尔大学 2020-02-11 CN disclosed