SCHEMBL28355480

SCHEMBL28355480

NC(=S)S.c1ccc(CN2CCCC2)cc1

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 3/20 0.59
PHGDH O43175 1/20 0.56
MGLL Q99685 1/20 0.56
HRH3 Q9Y5N1 3/20 0.53
TSHR P16473 1/20 0.52
ALDH1A1 P00352 3/20 0.50
PRMT6 Q96LA8 1/20 0.50
HPGD P15428 1/20 0.50
DUSP3 P51452 1/20 0.50
PTPN5 P54829 1/20 0.50
PTPN11 Q06124 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C19 P33261 1/20 0.50
MC4R P32245 1/20 0.50
KDM4E B2RXH2 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28142005 0.86 SIGMAR1 (0.66) SIGMAR1PHGDHMGLLHRH3TSHR
Carbamic Acid SCHEMBL6249677 0.85 TSHR (0.63) SIGMAR1HRH3TSHRALDH1A1CYP2D6
SCHEMBL28021237 0.85 SIGMAR1 (0.64) SIGMAR1PHGDHMGLLHRH3TSHR
SCHEMBL10436631 0.85 SIGMAR1 (0.74) SIGMAR1PHGDHMGLLHRH3TSHR
SCHEMBL1777747 0.84 SIGMAR1 (0.81) SIGMAR1HRH3ALDH1A1PRMT6CYP2D6
SCHEMBL13952 0.84 SIGMAR1 (0.81) SIGMAR1HRH3ALDH1A1PRMT6CYP2D6
Ammonia Solution, Strong SCHEMBL3699405 0.82 SIGMAR1 (0.77) SIGMAR1HRH3ALDH1A1PRMT6CYP2D6
SCHEMBL688047 0.82 SIGMAR1 (0.77) SIGMAR1HRH3ALDH1A1CYP2D6CYP2C19
SCHEMBL11141692 0.82 SIGMAR1 (0.77) SIGMAR1HRH3ALDH1A1CYP2D6CYP2C19
SCHEMBL11585348 0.82 SIGMAR1 (0.77) SIGMAR1HRH3ALDH1A1CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110683975-B Synthesis method of dialkyl amino alkyl dithioformate 成都理工大学 2021-04-09 CN disclosed
CN-110683975-A Synthesis method of dialkyl amino alkyl dithioformate 成都理工大学 2020-01-14 CN disclosed