Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.77 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.77 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | MC4R | P32245 | 1/20 | 0.63 |
| ▸ | DRD4 | P21917 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327 | 1.00 | SIGMAR1 (0.77) | SIGMAR1HRH3HRH4CYP2D6CYP2C19 | |
| SCHEMBL26532 | 1.00 | SIGMAR1 (0.77) | SIGMAR1HRH3HRH4CYP2D6CYP2C19 | |
| SCHEMBL11585348 | 1.00 | SIGMAR1 (0.77) | SIGMAR1HRH3HRH4CYP2D6CYP2C19 | |
| SCHEMBL11141692 | 1.00 | SIGMAR1 (0.77) | SIGMAR1HRH3HRH4CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL7409551 | 0.98 | SIGMAR1 (0.74) | SIGMAR1HRH3HRH4CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL4774633 | 0.98 | SIGMAR1 (0.74) | SIGMAR1HRH3HRH4CYP2D6CYP2C19 | |
| Bromide SCHEMBL10730905 | 0.98 | SIGMAR1 (0.74) | SIGMAR1HRH3HRH4CYP2D6CYP2C19 | |
| SCHEMBL13952 | 0.98 | SIGMAR1 (0.81) | SIGMAR1HRH3HRH4CYP2D6CYP2C19 | |
| SCHEMBL1777747 | 0.98 | SIGMAR1 (0.81) | SIGMAR1HRH3HRH4CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL5923800 | 0.96 | SIGMAR1 (0.71) | SIGMAR1HRH3HRH4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 315 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6384031-B1 | — | — | None | — | — | US | claimed |
| US-6392040-B1 | — | — | None | — | — | US | claimed |
| CN-110248939-B | Tyrosine amide derivatives as RHO-kinase inhibitors | 奇斯药制品公司 | 2022-05-17 | — | — | CN | claimed |
| US-10954236-B2 | Tyrosine amide derivatives as Rho-Kinase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2021-03-23 | — | — | US | claimed |
| EP-3573987-B1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2021-03-10 | — | — | EP | claimed |
| US-20200079774-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2020-03-12 | — | — | US | claimed |
| US-20180215758-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-08-02 | — | — | US | claimed |
| WO-2018138293-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-08-02 | — | — | WO | claimed |
| EP-2770987-B1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2018-04-04 | — | — | EP | claimed |
| CN-107074788-A | Substituted heterocyclic derivatives, preparation method and application thereof | 厦门大学 | 2017-08-18 | — | — | CN | claimed |
| EP-0161588-B1 | DIAMINO ACID DERIVATIVES | MERCK PATENT GmbH (DE) | 1990-08-16 | — | — | EP | claimed |
| EP-0157260-B1 | 4,7-DIHYDROPYRAZOLO(3,4-B)PYRIDINE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 1990-06-13 | — | — | EP | claimed |
| US-4895842-A | Phenylalanine derivative and proteinase inhibitor | SHOSUKE OKAMOTO (JP) | 1990-01-23 | — | — | US | claimed |
| US-4873334-A | HYPOTENSIVE AGENTS, CORONARY VASODILATORS | SHIONOGI & CO., LTD. (JP) | 1989-10-10 | — | — | US | claimed |
| US-4746649-A | Diamino acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1988-05-24 | — | — | US | claimed |
| EP-0238211-A2 | Dihydropyridines, process for their preparation and their use as medicaments | GLAXO S.p.A. (IT) | 1987-09-23 | — | — | EP | claimed |
| EP-0217286-A1 | Phenylalanine derivative and proteinase inhibitor | Okamoto, Shosuke (JP) | 1987-04-08 | — | — | EP | claimed |
| EP-0179352-A2 | Peptides | MERCK PATENT GmbH (DE) | 1986-04-30 | — | — | EP | claimed |
| EP-0161588-A2 | Diamino acid derivatives | MERCK PATENT GmbH (DE) | 1985-11-21 | — | — | EP | claimed |
| EP-0157260-A1 | 4,7-Dihydropyrazolo(3,4-b)Pyridine derivatives | SHIONOGI & CO., LTD. (JP) | 1985-10-09 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10954236-B2 | Tyrosine amide derivatives as Rho-Kinase inhibitors | ROCK1, ROCK2, CIT | SIGMAR1 3444/4885HRH3 309/4885HRH4 398/4885 |
| US-20200079774-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | ROCK1, ROCK2, CIT | SIGMAR1 3444/4885HRH3 309/4885HRH4 398/4885 |
| US-20180215758-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | ROCK1, ROCK2, CIT | SIGMAR1 3444/4885HRH3 309/4885HRH4 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.