Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 10/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.51 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.51 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28352248 | 0.83 | HPGD (0.63) | HPGDALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL28355798 | 0.82 | HPGD (0.69) | HPGDALDH1A1HSD11B1MEN1KMT2A | |
| SCHEMBL6554857 | 0.81 | HPGD (0.71) | HPGDALDH1A1HSD11B1MEN1KMT2A | |
| SCHEMBL19088577 | 0.79 | HPGD (0.73) | HPGDALDH1A1HSD11B1MEN1KMT2A | |
| SCHEMBL20456915 | 0.79 | L3MBTL3 (0.59) | HPGDALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL4002578 | 0.79 | HPGD (0.69) | HPGDALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL23675251 | 0.79 | HPGD (0.71) | HPGDALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6280995 | 0.79 | HPGD (0.96) | HPGDALDH1A1HSD11B1MEN1KMT2A | |
| SCHEMBL69263 | 0.78 | KDM4E (0.62) | HPGDALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL15499084 | 0.77 | HPGD (0.75) | HPGDALDH1A1HSD11B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110759889-B | 2-aryl amido substituted thiophene imide ester compound and preparation method and application thereof | 中国医学科学院药物研究所 | 2022-05-20 | — | — | CN | disclosed |
| CN-110759889-A | 2-aryl amido substituted thiophene imide ester compound and preparation method and application thereof | 中国医学科学院药物研究所 | 2020-02-07 | — | — | CN | disclosed |