Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 3/20 | 0.35 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28357607 | 0.88 | HTR6 (0.39) | MEN1KMT2ATP53LMNAHTR6 | |
| SCHEMBL21507141 | 0.78 | MEN1 (0.36) | MEN1KMT2A | |
| SCHEMBL28361064 | 0.78 | CSNK1D (0.36) | MEN1KMT2ATP53LMNAHTR6 | |
| SCHEMBL19780856 | 0.77 | UCHL1 (0.34) | MEN1KMT2AMAPTALDH1A1NR1H2 | |
| SCHEMBL21507138 | 0.76 | SCN9A (0.34) | MEN1KMT2ATACR1GPR119 | |
| SCHEMBL28357282 | 0.75 | ELANE (0.36) | MEN1KMT2ANR1H2NR1H3GPR119 | |
| SCHEMBL17925739 | 0.75 | HDAC1 (0.37) | TACR1NR1H2NR1H3GPR119 | |
| SCHEMBL17925736 | 0.75 | HDAC1 (0.37) | TACR1NR1H2NR1H3GPR119 | |
| SCHEMBL17936919 | 0.74 | SCN9A (0.34) | NR1H2GPR119 | |
| SCHEMBL17936918 | 0.74 | HDAC1 (0.36) | MEN1KMT2AGPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110804061-B | Pyrazole and pyrazine formamide compound containing cyclopropyl segment and application thereof | 中国医学科学院医药生物技术研究所 | 2021-01-05 | — | — | CN | disclosed |
| CN-110804061-A | Pyrazole and pyrazine formamide compound containing cyclopropyl segment and application thereof | 中国医学科学院医药生物技术研究所 | 2020-02-18 | — | — | CN | disclosed |