Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28357473 | 0.88 | MEN1 (0.39) | HTR6ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL28361064 | 0.83 | CSNK1D (0.36) | HTR6ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL28357608 | 0.82 | — | — | |
| SCHEMBL28357280 | 0.80 | CCR5 (0.31) | — | |
| SCHEMBL28357336 | 0.79 | MAPT (0.31) | — | |
| SCHEMBL28361054 | 0.77 | HTR6 (0.41) | HTR6ALDH1A1LMNABRD4HTR2A | |
| SCHEMBL28361041 | 0.76 | CSNK1D (0.36) | — | |
| SCHEMBL28357291 | 0.76 | MAPT (0.30) | — | |
| SCHEMBL28357358 | 0.76 | GRM4 (0.42) | LMNA | |
| SCHEMBL28361088 | 0.74 | HTR6 (0.33) | HTR6LMNAMEN1KMT2AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110804061-B | Pyrazole and pyrazine formamide compound containing cyclopropyl segment and application thereof | 中国医学科学院医药生物技术研究所 | 2021-01-05 | — | — | CN | disclosed |
| CN-110804061-A | Pyrazole and pyrazine formamide compound containing cyclopropyl segment and application thereof | 中国医学科学院医药生物技术研究所 | 2020-02-18 | — | — | CN | disclosed |