Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CDC25A | P30304 | 1/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27549947 | 0.78 | AADAT (0.42) | AADATKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL16376952 | 0.75 | AADAT (0.36) | AADATKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL19545773 | 0.73 | MAPT (0.35) | AADATKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL28698842 | 0.72 | CDC25A (0.41) | AADATKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL23803182 | 0.68 | CES2 (0.41) | KMT2AALDH1A1KDM4ECDC25ALMNA | |
| SCHEMBL20495415 | 0.68 | CES2 (0.41) | KMT2AALDH1A1KDM4ECDC25ALMNA | |
| SCHEMBL31499341 | 0.66 | ESR1 (0.39) | KDM4EEGFR | |
| SCHEMBL7249195 | 0.65 | ALDH1A1 (0.48) | ALDH1A1P2RX4LMNAGAASMN1; SMN2 | |
| SCHEMBL25339554 | 0.65 | IDO1 (0.41) | KMT2AMEN1ALDH1A1KDM4ECDC25A | |
| SCHEMBL31274704 | 0.65 | BCHE (0.52) | AADATNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110709396-A | Novel compound inhibitors of the YAP/TAZ-TEAD interaction and their use in the treatment of malignant mesothelioma | 伊文蒂瓦公司 | 2020-01-17 | — | — | CN | disclosed |