Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 3/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922674 | 1.00 | INSR (0.45) | INSRALKLRRK2MAPK8MAPK9 | |
| SCHEMBL28359418 | 0.87 | TYK2 (0.54) | MAPK9MAPK10JAK2CDK2SYK | |
| SCHEMBL29922581 | 0.85 | JAK2 (0.52) | JAK2MAPK1MAPTMEN1NPC1 | |
| SCHEMBL28359240 | 0.85 | JAK2 (0.52) | JAK2MAPK1MAPTMEN1NPC1 | |
| SCHEMBL29552105 | 0.81 | DGAT1 (0.49) | CSF1RMAPTRAB9ASMN1; SMN2GAA | |
| SCHEMBL29922819 | 0.81 | DGAT1 (0.49) | CSF1RMAPTRAB9ASMN1; SMN2GAA | |
| SCHEMBL28359065 | 0.81 | DGAT1 (0.49) | CSF1RMAPTRAB9ASMN1; SMN2GAA | |
| SCHEMBL29552999 | 0.74 | TYK2 (0.57) | MAPK8JAK2AURKACDK2SYK | |
| SCHEMBL29552398 | 0.72 | JAK2 (0.54) | MAPK8MAPK9MAPK10JAK2AURKA | |
| SCHEMBL25771640 | 0.72 | MAPT (0.49) | FGFR3MAPK1MAPTMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |