Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 4/20 | 0.52 |
| ▸ | TYK2 | P29597 | 4/20 | 0.52 |
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | JAK3 | P52333 | 3/20 | 0.52 |
| ▸ | CDC25B | P30305 | 7/20 | 0.44 |
| ▸ | CDC25A | P30304 | 1/20 | 0.44 |
| ▸ | CDC25C | P30307 | 1/20 | 0.44 |
| ▸ | RHOA | P61586 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29551925 | 1.00 | JAK1 (0.52) | JAK1TYK2JAK2JAK3CDC25B | |
| SCHEMBL29552249 | 0.90 | TYK2 (0.58) | JAK1TYK2JAK2JAK3AURKA | |
| SCHEMBL28359236 | 0.90 | TYK2 (0.58) | JAK1TYK2JAK2JAK3AURKA | |
| SCHEMBL29551888 | 0.89 | JAK2 (0.59) | JAK1TYK2JAK2JAK3MAPT | |
| SCHEMBL28358981 | 0.84 | JAK1 (0.47) | JAK1TYK2JAK2JAK3NPC1 | |
| SCHEMBL29551854 | 0.84 | JAK1 (0.47) | JAK1TYK2JAK2JAK3NPC1 | |
| SCHEMBL29551995 | 0.83 | JAK2 (0.69) | JAK1TYK2JAK2JAK3NPC1 | |
| SCHEMBL28359167 | 0.83 | JAK2 (0.69) | JAK1TYK2JAK2JAK3NPC1 | |
| SCHEMBL29551873 | 0.81 | TYK2 (0.52) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL29922823 | 0.81 | JAK2 (0.51) | JAK1TYK2JAK2JAK3CDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |