Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL3952132 | 0.88 | TSHR (0.45) | TSHRRARBALDH1A1TDP1SMN1; SMN2 | |
| Terephthalic Acid SCHEMBL6554172 | 0.87 | TSHR (0.57) | TSHRTP53RARBMAPK1ALOX15 | |
| Terephthalic Acid SCHEMBL375131 | 0.87 | TSHR (0.57) | TSHRTP53RARBMAPK1ALOX15 | |
| Terephthalic Acid SCHEMBL674458 | 0.85 | TSHR (0.55) | TSHRTP53RARBMAPK1ALOX15 | |
| Tetraethylene Glycol SCHEMBL3841162 | 0.85 | TSHR (0.55) | TSHRTP53RARBMAPK1ALOX15 | |
| Terephthalic Acid SCHEMBL9165497 | 0.85 | TSHR (0.55) | TSHRTP53RARBMAPK1ALOX15 | |
| Terephthalic Acid SCHEMBL10383285 | 0.85 | TSHR (0.55) | TSHRTP53RARBMAPK1ALOX15 | |
| Terephthalic Acid SCHEMBL27506116 | 0.85 | TSHR (0.55) | TSHRTP53RARBMAPK1ALOX15 | |
| Terephthalic Acid SCHEMBL31548541 | 0.83 | TSHR (0.52) | TSHRTP53RARBMAPK1ALOX15 | |
| Benzoic Acid SCHEMBL3956351 | 0.81 | TSHR (0.54) | HSD17B10TSHRTP53RARBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110835407-A | Polyester polyol, method for producing same, and polyurethane foam material | 远东新世纪股份有限公司 | 2020-02-25 | — | — | CN | disclosed |