Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL375131 | 1.00 | TSHR (0.57) | TSHRTP53SRD5A2PKMCA1 | |
| Terephthalic Acid SCHEMBL27506116 | 0.98 | TSHR (0.55) | TSHRTP53SRD5A2PKMCA1 | |
| Terephthalic Acid SCHEMBL9165497 | 0.98 | TSHR (0.55) | TSHRTP53SRD5A2PKMCA1 | |
| Terephthalic Acid SCHEMBL674458 | 0.98 | TSHR (0.55) | TSHRTP53SRD5A2PKMCA1 | |
| Tetraethylene Glycol SCHEMBL3841162 | 0.98 | TSHR (0.55) | TSHRTP53SRD5A2PKMCA1 | |
| Terephthalic Acid SCHEMBL10383285 | 0.98 | TSHR (0.55) | TSHRTP53SRD5A2PKMCA1 | |
| Terephthalic Acid SCHEMBL31548541 | 0.96 | TSHR (0.52) | TSHRTP53SRD5A2PKMCA1 | |
| Terephthalic Acid SCHEMBL28153509 | 0.92 | TSHR (0.48) | TSHRTP53SRD5A2PKMCA1 | |
| Paraben SCHEMBL133368 | 0.92 | CA2 (0.64) | TSHRTP53SRD5A2PKMCA1 | |
| Benzoic Acid SCHEMBL818565 | 0.91 | TSHR (0.61) | TSHRTP53SRD5A2PKMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200299454-A1 | IMIDE-CONTAINING POLYESTER | COVESTRO DEUTSCHLAND AG (DE) | 2020-09-24 | — | — | US | disclosed |
| CN-106478890-B | A kind of polyurethane/polyvinyl acetate hybridisation emulsion and preparation method thereof | 佛山市顺德区巴德富实业有限公司 | 2019-02-12 | — | — | CN | disclosed |
| CN-107964377-A | A kind of awning high density waterproof cloth | 成都杰雷遮阳工程有限公司 | 2018-04-27 | — | — | CN | disclosed |
| CN-104003840-B | A kind of method being prepared 1,4 cyclohexane dimethanol by waste PET degraded monomers terephthalic acid binaryglycol ester | 中国科学院过程工程研究所 | 2016-06-22 | — | — | CN | disclosed |
| CN-105294393-A | Method for preparing 1,4-cyclohexanedimethanol through one-pot hydrogenation | INST PROCESS ENG CAS | 2016-02-03 | — | — | CN | disclosed |
| CN-104003840-A | Method for preparing 1,4-cyclohexanedimethanol from waste PET (polyethylene glycol terephthalate) degradation monomer diethylene glycol terephthalate | INST PROCESS ENG CAS | 2014-08-27 | — | — | CN | disclosed |
| CN-101875718-B | Conductive polyester/graphite oxide composite material and preparation method thereof | TORAY FIBER RES INST CN CO LTD | 2012-10-17 | — | — | CN | disclosed |
| CN-1834131-A | Water-soluable sizing material polyester and prepn. thereof | NANFENG POLYESTER CO LTD LUOYA (CN) | 2006-09-20 | — | — | CN | disclosed |
| CN-1529160-A | Method gel-chromatographic analysis of terephthalates compounds | 中国科学院山西煤炭化学研究所 | 2004-09-15 | — | — | CN | disclosed |
| EP-0710165-B1 | POLYURETHANE-FORMING BINDER SYSTEMS CONTAINING 2,2'-DIPYRIDYL, 1,10-PHENANTHROLINE, AND THEIR SUBSTITUTED ALKYL DERIVATIVES | ASHLAND OIL INC (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-0710165-A4 | POLYURETHANE-FORMING BINDER SYSTEMS CONTAINING 2,2'-DIPYRIDYL, 1,10-PHENANTHROLINE, AND THEIR SUBSTITUTED ALKYL DERIVATIVES | ASHLAND OIL INC (US) | 1996-10-02 | — | — | EP | disclosed |
| EP-0710165-A1 | POLYURETHANE-FORMING BINDER SYSTEMS CONTAINING 2,2'-DIPYRIDYL, 1,10-PHENANTHROLINE, AND THEIR SUBSTITUTED ALKYL DERIVATIVES | ASHLAND OIL, INC. (US) | 1996-05-08 | — | — | EP | disclosed |
| US-5447968-A | Aggregates, binders and phenolic resins with polyisocyanates | ASHLAND INC. (US) | 1995-09-05 | — | — | US | disclosed |
| WO-1995003903-A2 | POLYURETHANE BINDER SYSTEMS CONTAINING 2,2'-DIPYRIDYL, 1,10-PHENANTHROLINE, AND DERIVATIVES | ASHLAND OIL, INC. (US) | 1995-02-09 | — | — | WO | disclosed |
| US-4726968-A | EMULSION POLYMERIZATION OF WATER-SOLUBLE CROSSLINKING VINYL MONOMER | INTERA COMPANY, LTD., A TENNESSEE LIMITED PARTNERSHIP (US) | 1988-02-23 | — | — | US | disclosed |
| US-4724892-A | RAPID CURING; HIGH TENSILE STRENGHT; FOUNDRY MOLDING | ASHLAND OIL, INC. (US) | 1988-02-16 | — | — | US | disclosed |
| EP-0231270-A4 | SELF-SETTING URETHANE ADHESIVE PASTE SYSTEM. | ASHLAND OIL INC (US) | 1987-11-23 | — | — | EP | disclosed |
| US-4692479-A | BONDING FOUNDRY SHAPES | ASHLAND OIL, INC. (US) | 1987-09-08 | — | — | US | disclosed |
| EP-0231270-A1 | SELF-SETTING URETHANE ADHESIVE PASTE SYSTEM | ASHLAND OIL, INC. (US) | 1987-08-12 | — | — | EP | disclosed |
| WO-1987000459-A1 | SELF-SETTING URETHANE ADHESIVE PASTE SYSTEM | ASHLAND OIL, INC. (US) | 1987-01-29 | — | — | WO | disclosed |