Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | RARB | P10826 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL674458 | 1.00 | TSHR (0.55) | TSHRTP53MEN1KMT2ARARB | |
| Terephthalic Acid SCHEMBL27506116 | 1.00 | TSHR (0.55) | TSHRTP53MEN1KMT2ARARB | |
| Tetraethylene Glycol SCHEMBL3841162 | 1.00 | TSHR (0.55) | TSHRTP53MEN1KMT2ARARB | |
| Terephthalic Acid SCHEMBL31548541 | 0.98 | TSHR (0.52) | TSHRTP53MEN1KMT2ARARB | |
| Terephthalic Acid SCHEMBL375131 | 0.98 | TSHR (0.57) | TSHRTP53MEN1KMT2ARARB | |
| Terephthalic Acid SCHEMBL6554172 | 0.98 | TSHR (0.57) | TSHRTP53MEN1KMT2ARARB | |
| Terephthalic Acid SCHEMBL9165497 | 0.95 | TSHR (0.55) | TSHRTP53MEN1KMT2ARARB | |
| Paraben SCHEMBL3364114 | 0.92 | CA2 (0.61) | TSHRTP53MEN1KMT2ARARB | |
| Triethylene Glycol SCHEMBL5730892 | 0.91 | TSHR (0.58) | TSHRTP53MEN1KMT2ARARB | |
| Triethylene Glycol SCHEMBL205789 | 0.91 | TSHR (0.58) | TSHRTP53MEN1KMT2ARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4931524-A | SACCHARIDE/URETHANE ETHER WITH PARTIAL BLOCKING AND HYDRO-PHILIC MOIETY; ETHERIFICATION | DAI-ICHI KOGYO SEIYAKU CO., LTD. (JP) | 1990-06-05 | — | — | US | disclosed |