Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MDM4 | O15151 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13701715 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL9737620 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL9736861 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL13702282 | 0.76 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL22898321 | 0.75 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL12471403 | 0.73 | POLB (0.54) | SMN1; SMN2NPC1POLB | |
| SCHEMBL27515551 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL24003686 | 0.71 | P2RX7 (0.64) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1467988 | 0.71 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL6972329 | 0.70 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAALDH1A1EGFRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110642782-A | (S) -2- (2-chloronicotinylamino) propyl propionate derivative and preparation method and application thereof | 浙江工业大学 | 2020-01-03 | — | — | CN | claimed |