Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828593 | 0.80 | LMNA (0.61) | SMN1; SMN2LMNATDP1POLBL3MBTL1 | |
| SCHEMBL24198699 | 0.79 | TDP1 (0.40) | SMN1; SMN2LMNATDP1KMT2APOLB | |
| SCHEMBL6710903 | 0.78 | LMNA (0.58) | SMN1; SMN2LMNATDP1KMT2APOLB | |
| SCHEMBL24198798 | 0.76 | EGFR (0.41) | SMN1; SMN2LMNATDP1KMT2APOLB | |
| SCHEMBL28360960 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNATDP1KMT2APOLB | |
| SCHEMBL18948157 | 0.75 | P2RX7 (0.39) | SMN1; SMN2LMNATDP1KMT2AALDH1A1 | |
| SCHEMBL8237046 | 0.74 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNATDP1KMT2APOLB | |
| SCHEMBL18387841 | 0.73 | ALDH1A1 (0.50) | SMN1; SMN2LMNAKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL18648101 | 0.72 | ERCC5 (0.42) | SMN1; SMN2TDP1KMT2AALDH1A1HPGD | |
| Heptane SCHEMBL28734342 | 0.72 | SMN1; SMN2 (0.74) | SMN1; SMN2LMNATDP1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210015100-A1 | SUBSTITUTED PYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2021-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210015100-A1 | SUBSTITUTED PYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF | GART, BROX, APRT | SMN1; SMN2 3356/4885LMNA 3838/4885TDP1 1393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.